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However, the diagnosis of pain is challenging due to the heterogeneous and nonspecific symptoms. Practical guidance on the diagnosis and management of pain in\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      is needed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 2014, experts met to discuss recent advances on this topic and update clinical guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Emerging disease\u2010specific tools, including FabryScan, Fabry\u2010specific Pediatric Health and Pain Questionnaire, and W\u00fcrzburg Fabry Pain Questionnaire, and more general tools like the Total Symptom Score can aid diagnosis, characterization, and monitoring of pain in patients with\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      . These tools can be complemented by more objective and quantifiable sensory testing. In male and female patients of any age, pain related to\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      can be an early indication to start disease\u2010specific enzyme replacement therapy before potentially irreversible organ damage to the kidneys, heart, or brain occurs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      To improve treatment outcomes, pain should be diagnosed early in unrecognized or newly identified\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients. Treatment should include: (a) enzyme replacement therapy controlling the progression of underlying pathology; (b) adjunctive, symptomatic pain management with analgesics for chronic neuropathic and acute nociceptive, and inflammatory or mixed pain; and (c) lifestyle modifications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.12542","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T06:39:50Z","timestamp":1459147190000},"page":"568-576","source":"Crossref","is-referenced-by-count":102,"title":["Pain in Fabry Disease: Practical Recommendations for Diagnosis and Treatment"],"prefix":"10.1111","volume":"22","author":[{"given":"Juan M.","family":"Politei","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n para el Estudio de las Enfermedades Neurometab\u00f3licas (FESEN) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Bouhassira","sequence":"additional","affiliation":[{"name":"INSERM U\u2010987 Centre d'Evaluation et de Traitement de la Douleur H\u00f4pital Ambroise Par\u00e9 Boulogne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique P.","family":"Germain","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics University of Versailles \u2010 St Quentin en Yvelines Paris\u2010Saclay University Montigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Goizet","sequence":"additional","affiliation":[{"name":"CHU Bordeaux H\u00f4pital Pellegrin Service de G\u00e9n\u00e9tique M\u00e9dicale and Universit\u00e9 Bordeaux Laboratoire Maladies Rares: G\u00e9n\u00e9tique et M\u00e9tabolisme (MRGM) EA4576 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Guerrero\u2010Sola","sequence":"additional","affiliation":[{"name":"Neuromuscular Unit Neurology Department Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max J.","family":"Hilz","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Erlangen\u2010Nuremberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth J.","family":"Hutton","sequence":"additional","affiliation":[{"name":"Department of Neurology The Alfred Hospital Melbourne Vic. 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