{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:54:14Z","timestamp":1772985254857,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Ministry of Science and Technology of China","award":["2011BAI08B02"],"award-info":[{"award-number":["2011BAI08B02"]}]},{"name":"Ministry of Science and Technology of China","award":["2013BAI09B03"],"award-info":[{"award-number":["2013BAI09B03"]}]},{"name":"Ministry of Science and Technology of China","award":["2015BAI12B04"],"award-info":[{"award-number":["2015BAI12B04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the management of low\u2010density lipoprotein cholesterol (\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C) in patients suffering from ischemic stroke within 6\u201312\u00a0months and explore the predictors of the achievement of\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C target.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was a nation\u2010wide, multicenter, cross\u2010sectional study conducted from July 2013 to August 2013 in mainland China. Patients who had an ischemic stroke within 6\u201312\u00a0months and were more than 18\u00a0year old were consecutively included into this study. All data referred to personal information, medical history, medication and results from laboratory tests were collected by face\u2010to\u2010face questionnaires, physical examination and blood tests. The predictors for the achievement of\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C target (&lt;1.8\u00a0mmol\/L or &lt;70\u00a0mg\/\n                      <jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>\n                      ) were analyzed by the multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3956 cases from 56 centers who suffered from ischemic stroke within 6\u201312\u00a0months were finally included into this study. The average serum level of\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C in all patients was 2.42\u00a0\u00b1\u00a00.91\u00a0mmol\/L with a median of 2.30\u00a0mmol\/L and the total\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C goal achievement rate was 27.4% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 26.0%\u201028.8%). Lipid\u2010lowering therapy (odds ratio [\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      ]\u00a0=\u00a03.54, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 2.879\u20134.388) was the most significant predictor for\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C target achievement and female (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a00.64, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.526\u20130.777), current smoking (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a00.714, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.571\u20130.892), and the history of dyslipidemia (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a00.577, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.497\u20130.668) were other three important negative factors for the\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C goal achievement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although lipid modulation is recommended as an important intervention for stroke patients in the international guidelines, the goal achievement of\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010C is still very low in this population in mainland China. The modifiable predictors including the use of lipid\u2010lowering medication and smoking cessation should be improved in secondary prevention of stroke.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.12543","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T03:25:17Z","timestamp":1465874717000},"page":"577-583","source":"Crossref","is-referenced-by-count":13,"title":["The Management of\n                    <scp>LDL<\/scp>\n                    Cholesterol and Predictors of Goal Achievement in Stroke Patients in China: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"22","author":[{"given":"Chun\u2010Juan","family":"Wang","sequence":"first","affiliation":[{"name":"Tiantan Clinical Trial and Research Center for Stroke Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing 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