{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:41:16Z","timestamp":1790041276743,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102453"],"award-info":[{"award-number":["81102453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Acute cerebral ischemia may lead to ischemic stroke, which is a major cause of death and disability worldwide. Hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) functions importantly in mammalian systems. The present work was designed to study the effect of sodium sulfide, a donor of H\n                      <jats:sub>2<\/jats:sub>\n                      S, on acute cerebral ischemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Acute cerebral focal ischemia was produced by middle cerebral artery occlusion (\n                      <jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>\n                      ) in Sprague\u2010Dawley (\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      ) rats. Bilateral vertebral arteries and common carotid arteries were blocked to establish cerebral global ischemia in\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      rats. Acute cerebral anoxia was produced by hypobaric anoxia in C57BL\/6 mice and hypoxic anoxia in\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      rats. Nimodipine and aspirin were set as positive control separately.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Infarct size after\n                      <jats:styled-content style=\"fixed-case\">MCAO<\/jats:styled-content>\n                      was decreased by sodium sulfide. Sodium sulfide improved cerebral energy metabolism after cerebral global ischemia and prolonged survival time of animals with acute cerebral anoxia. In addition, increased cerebral blood flow and decreased cerebrovascular resistance, blood viscosity, and thrombogenesis were observed in animals treated with sodium sulfide. In cultured neurons, sodium sulfide increased cell viability and decreased cell apoptosis induced by oxygen\u2010glucose deprivation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Sodium sulfide, a H\n                      <jats:sub>2<\/jats:sub>\n                      S donor, presents protective effect on acute cerebral ischemia, and might be a promising therapeutic drug.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.12558","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T01:04:08Z","timestamp":1462842248000},"page":"625-632","source":"Crossref","is-referenced-by-count":26,"title":["Sodium Sulfide, a Hydrogen Sulfide\u2010Releasing Molecule, Attenuates Acute Cerebral Ischemia in 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