{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:24:14Z","timestamp":1773797054010,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171183"],"award-info":[{"award-number":["81171183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230028"],"award-info":[{"award-number":["81230028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301044"],"award-info":[{"award-number":["81301044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471221"],"award-info":[{"award-number":["81471221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471535"],"award-info":[{"award-number":["81471535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS092713"],"award-info":[{"award-number":["R01NS092713"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16SDG27250236"],"award-info":[{"award-number":["16SDG27250236"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluate safety and efficacy of autologous bone marrow\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s) as a potential treatment for neuromyelitis optica spectrum disorder (<jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> were recruited. All patients received a single intravenous infusion of 1.0 \u00d7 10<jats:sup>8<\/jats:sup> autologous <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> within 3\u20134 generations derived from bone marrow. The primary endpoints of the study were efficacy as reflected by reduction in annualized relapse rates (<jats:styled-content style=\"fixed-case\">ARR<\/jats:styled-content>s) and inflammatory lesions observed by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12 months after <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> infusion, the mean <jats:styled-content style=\"fixed-case\">ARR<\/jats:styled-content> was reduced (1.1 vs. 0.3, <jats:italic>P<\/jats:italic> = 0.002), and the T2 or gadolinium\u2010enhancing T1 lesions decreased in the optic nerve and spinal cord. Disability in these patients was reduced (<jats:styled-content style=\"fixed-case\">EDSS<\/jats:styled-content>, 4.3 vs. 4.9, <jats:italic>P<\/jats:italic> = 0.021; visual acuity, 0.4 vs. 0.5, <jats:italic>P<\/jats:italic> = 0.007). The patients had an increase in retinal nerve fiber layer thickness, optic nerve diameters and upper cervical cord area. We did not identify any serious <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\u2010related adverse events. At 24 months of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> infusion, of 15 patients, 13 patients (87%) remained relapse\u2010free, the mean <jats:styled-content style=\"fixed-case\">ARR<\/jats:styled-content> decreased to 0.1; the disability of 6 patients (40%) was improved, and the mean <jats:styled-content style=\"fixed-case\">EDSS<\/jats:styled-content> decreased to 4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This pilot trial demonstrates that <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> infusion is safe, reduces the relapse frequency, and mitigates neurological disability with neural structures in the optic nerve and spinal cord recover in patients with <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content>. The beneficial effect of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> infusion on <jats:styled-content style=\"fixed-case\">NMOSD<\/jats:styled-content> was maintained, at least to some degree, throughout a 2\u2010year observational period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12559","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T02:01:43Z","timestamp":1464141703000},"page":"677-685","source":"Crossref","is-referenced-by-count":35,"title":["Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2\u2010Year Observational Study"],"prefix":"10.1111","volume":"22","author":[{"given":"Ying","family":"Fu","sequence":"first","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Yan","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qi","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningnannan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunshui","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Su","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Lin","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"},{"name":"Department of Neurology Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghong","family":"Shao","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongchao","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Dong","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Radiology, Ophthalmology, Hematology Tianjin Medical University General Hospital Tianjin Medical University Eye Hospital Tianjin China"},{"name":"Department of Neurology Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70133-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0764"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-85"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049912.02954.2C"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d31e35"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.188"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.216"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431973"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aac7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70076-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.141"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00240-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3209"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3163"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1496"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123463"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.021"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113936"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.07.013"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.248"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70305-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X586756"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d26968"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq146"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182152881"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.11.011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23612"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20501"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.06.001"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653240903253857"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306075793"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404466"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.12559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.12559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:31:06Z","timestamp":1695547866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.12559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/cns.12559"],"URL":"https:\/\/doi.org\/10.1111\/cns.12559","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}