{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:29:18Z","timestamp":1783603758482,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Altucell Inc."},{"name":"Consorzio Interuniversitario per Trapianti di Organo, Rome, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Immune dysfunction, promoted by pro\u2010inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The experimental R6\/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6\/2 Huntington's disease mice, by immune dysfunction modulation in brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12569","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T12:04:31Z","timestamp":1464264271000},"page":"686-690","source":"Crossref","is-referenced-by-count":18,"title":["Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease"],"prefix":"10.1111","volume":"22","author":[{"given":"Giovanni","family":"Luca","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bellezza","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Perugia Perugia 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