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Many of these modules, however, have not been previously linked to autism spectrum disorders which included G\u2010protein signaling, immunity, and neuroactive ligand\u2013receptor interaction pathway. The downregulation of the highly connected (hub) genes <jats:italic>Taar7h<\/jats:italic> and <jats:italic>Taar7b<\/jats:italic> in neuroactive ligand\u2013receptor interaction pathway was validated by <jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Immunoblotting and immunohistochemistry further showed that <jats:styled-content style=\"fixed-case\">TAAR<\/jats:styled-content>7 expression was downregulated not only in valproic acid\u2010treated animals, but also <jats:styled-content style=\"fixed-case\">BTBR<\/jats:styled-content> T+tf\/J mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the advantages of gene microarrays to uncover co\u2010expression modules associated with autism and suggests that <jats:italic>Taars<\/jats:italic> and related gene regulation networks may play a significant role in autism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12582","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T06:37:20Z","timestamp":1466404640000},"page":"845-853","source":"Crossref","is-referenced-by-count":29,"title":["Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of 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