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We aimed to investigate the neuroprotective effects of stereotactic administration of edaravone (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>) into the brain parenchyma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intracerebral hemorrhage rat models were established by infusion of collagenase into the caudate nucleus. Neural functional recovery was assessed using modified neurological severity scores (<jats:styled-content style=\"fixed-case\">mNSS<\/jats:styled-content>). A comparative study of therapeutic effects between<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>and intraperitoneal injection of edaravone (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>) involved in cerebral edema, blood\u2013brain barrier (<jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content>) permeability, hematoma absorption, inflammatory response and neuronal apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>, the<jats:styled-content style=\"fixed-case\">mNSS<\/jats:styled-content>was significantly (<jats:italic>P<\/jats:italic>&lt; 0.05) improved by<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>; cerebral edema and<jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content>permeability were dramatically ameliorated (<jats:italic>P<\/jats:italic>&lt; 0.05);<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 levels increased, but<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 levels significantly decreased; neuron apoptosis decreased markedly (<jats:italic>P<\/jats:italic>&lt; 0.05); and caspase\u20103 and Bax expression significantly dropped, but Bcl\u20102 increased in<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>group (<jats:italic>P<\/jats:italic>&lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>markedly improved neurological deficits in<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>rat models via antiinflammatory and antiapoptosis mechanisms and promoted M2\u2010type microglia differentiation.<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>was effective in rats with collagenase\u2010induced<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12584","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T08:38:42Z","timestamp":1467967122000},"page":"824-835","source":"Crossref","is-referenced-by-count":41,"title":["Stereotactic Administration of Edaravone Ameliorates Collagenase\u2010Induced Intracerebral Hemorrhage in Rat"],"prefix":"10.1111","volume":"22","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"The Third Military Medical University Chongqing China"},{"name":"Affiliated Bayi Brain Hospital Army General Hospital of PLA Beijing China"},{"name":"The Neurosurgical Research Center of Beijing Military Region Beijing 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