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Although they are traditionally known for their role in allergic asthma, allergic rhinitis, and others, recent advances in the field of biomedical research highlighted the role of these inflammatory mediators in a broader range of diseases such as in the inflammation associated with the central nervous system (\n                    <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\n                    ) disorders, vascular inflammation (atherosclerotic), and in cancer. Among the\n                    <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\n                    diseases, they, along with their synthesis precursor enzyme 5\u2010lipoxygenase and their receptors, have been shown to be associated with brain injury, Multiple sclerosis, Alzheimer's disease, Parkinson's disease, brain ischemia, epilepsy, and others. However, a lot more remains elusive as the research in these areas is emerging and only a little has been discovered. Herein, through this review, we first provided a general up\u2010to\u2010date information on the synthesis pathway and the receptors for the molecules. Next, we summarized the current findings on their role in the brain disorders, with an insight given to the future perspectives.\n                  <\/jats:p>","DOI":"10.1111\/cns.12596","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:22:46Z","timestamp":1471652566000},"page":"943-951","source":"Crossref","is-referenced-by-count":74,"title":["Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-749X","authenticated-orcid":false,"given":"Arijit","family":"Ghosh","sequence":"first","affiliation":[{"name":"Laboratory for Alzheimer's Disease and Related Disorders Department of Pharmacology China Pharmaceutical University Nanjing China"},{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory for Alzheimer's Disease and Related Disorders Department of Pharmacology China Pharmaceutical University Nanjing China"},{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhimanyu","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hong","sequence":"additional","affiliation":[{"name":"Laboratory for Alzheimer's Disease and Related Disorders Department of Pharmacology China Pharmaceutical University Nanjing China"},{"name":"Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University Nanjing 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