{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:49:26Z","timestamp":1789480166270,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>\n \n Aims<\/jats:title>\n \n Autism spectrum disorder (\n ASD<\/jats:styled-content>\n ) is a condition defined by social communication deficits and repetitive restrictive behaviors. Association of the fatty acid amide palmitoylethanolamide (\n PEA<\/jats:styled-content>\n ) with the flavonoid luteolin displays neuroprotective and antiinflammatory actions in different models of central nervous system pathologies. We hypothesized that association of\n PEA<\/jats:styled-content>\n with luteolin might have therapeutic utility in\n ASD<\/jats:styled-content>\n , and we employed a well\u2010recognized autism animal model, namely sodium valproate administration, to evaluate cognitive and motor deficits.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two sets of experiments were conducted. In the first, we investigated the effect of association of ultramicronized\n PEA<\/jats:styled-content>\n with luteolin, co\u2010ultramicronized\n PEA<\/jats:styled-content>\n \u2010\n LUT<\/jats:styled-content>\n \u00ae (co\u2010ultra\n PEA<\/jats:styled-content>\n \u2010\n LUT<\/jats:styled-content>\n \u00ae) in a murine model of autistic behaviors, while in the second, the effect of co\u2010ultra\n PEA<\/jats:styled-content>\n \u2010\n LUT<\/jats:styled-content>\n \u00ae in a patient affected by\n ASD<\/jats:styled-content>\n was examined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Co\u2010ultra\n PEA<\/jats:styled-content>\n \u2010\n LUT<\/jats:styled-content>\n \u00ae treatment ameliorated social and nonsocial behaviors in valproic acid\u2010induced autistic mice and improved clinical picture with reduction in stereotypes in a 10\u2010year\u2010old male child.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These data suggest that\n ASD<\/jats:styled-content>\n symptomatology may be improved by agents documented to control activation of mast cells and microglia. Co\u2010ultra\n PEA<\/jats:styled-content>\n \u2010\n LUT<\/jats:styled-content>\n \u00ae might be a valid and safe therapy for the symptoms of\n ASD<\/jats:styled-content>\n alone or in combination with other used drugs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cns.12648","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T11:05:19Z","timestamp":1476270319000},"page":"87-98","source":"Crossref","is-referenced-by-count":97,"title":["Beneficial Effects of Co\u2010Ultramicronized Palmitoylethanolamide\/Luteolin in a Mouse Model of Autism and in a Case Report of Autism"],"prefix":"10.1111","volume":"23","author":[{"given":"Bartolomeo","family":"Bertolino","sequence":"first","affiliation":[{"name":"Presidio Ospedaliero S.Antonio Abate via delle Naiadi Trapani Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Crupi","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmacological and Environmental Sciences University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Impellizzeri","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmacological and Environmental Sciences University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bruschetta","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmacological and Environmental Sciences University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Cordaro","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmacological and Environmental Sciences University of Messina Messina 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