{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:15:14Z","timestamp":1789874114473,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Asenapine is a new atypical antipsychotic prescribed for the treatment of psychosis\/bipolar disorders that presents higher affinity for serotonergic than dopaminergic receptors. The objective of this study was to investigate its antidepressant\u2010like and antimanic\u2010like properties on relevant animal models of depression and mania and to assess the acute and chronic effect of Asenapine on dorsal raphe nucleus (<jats:styled-content style=\"fixed-case\">DRN<\/jats:styled-content>) 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>cell firing activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the effects of Asenapine using in vivo electrophysiological and behavioral assays in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Behavioral experiments showed that Asenapine had no significant effect on immobility time in the forced swim test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>) in control rats. In the<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010treated rats, a model of antidepressant\u2010resistance, Asenapine failed to alter immobility time in the<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>. In contrast in the sleep deprivation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) model of mania, acute administration of Asenapine significantly decreased the hyperlocomotion of<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>rats. In the<jats:styled-content style=\"fixed-case\">DRN<\/jats:styled-content>, acute administration of Asenapine reduced the suppressant effect of the selective 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>7<\/jats:sub>receptor agonist<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\u201044 and of the prototypical 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1A<\/jats:sub>receptor agonist 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DPAT<\/jats:styled-content>on 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>neuronal firing activity. In addition, chronic treatment with Asenapine enhanced<jats:styled-content style=\"fixed-case\">DRN<\/jats:styled-content>5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>neuronal firing and this effect was associated with an alteration of the 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>7<\/jats:sub>receptor responsiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results confirm that Asenapine displays robust antimanic property and effective in vivo antagonistic activity at 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1A\/7<\/jats:sub>receptors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12698","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T04:32:41Z","timestamp":1492489961000},"page":"518-525","source":"Crossref","is-referenced-by-count":12,"title":["Asenapine modulates mood\u2010related behaviors and 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