{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:19:12Z","timestamp":1789201152628,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7\u2010PEOPLE\u20102011\u2010IEF"],"award-info":[{"award-number":["FP7\u2010PEOPLE\u20102011\u2010IEF"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyze brain functional connectivity in the somatomotor and default\u2010mode networks (DMNs) of patients with Huntington disease (HD), its relationship with gray matter (GM) volume loss, and functional changes after pridopidine treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients and ten untreated controls underwent T1\u2010weighted imaging and resting\u2010state functional magnetic resonance imaging (fMRI); four patients were also assessed after 3\u00a0months of pridopidine treatment (90\u00a0mg\/d). The seed\u2010based functional connectivity patterns from the posterior cingulate cortex and the supplementary motor area (SMA), considered cortical hubs of the DMN and somatomotor networks, respectively, were computed. FMRIB Software Library voxel\u2010based morphometry measured GM volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients had GM volume decrease in all cortical and subcortical areas of the somatomotor network with preservation of the SMA, and increased somatomotor and DMN connectivity. In DMN structures, functional connectivity impairment preceded volume loss. Pridopidine reduced the intensity of these aberrant connections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The abnormal connectivity of the somatomotor and DMN observed in HD patients may represent an early dysfunction marker, as it preceded volume loss in DMN. Pridopidine reduced connectivity of these networks in all four treated patients, suggesting that connectivity is sensitive to treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.12701","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T13:25:43Z","timestamp":1493731543000},"page":"488-497","source":"Crossref","is-referenced-by-count":22,"title":["Resting\u2010state connectivity and modulated somatomotor and default\u2010mode networks in Huntington disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Cristina","family":"S\u00e1nchez\u2010Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Department of Medicine School of Medicine and Health Sciences IDIBAPS Neuroscience Institute University of Barcelona  Barcelona Spain"},{"name":"Radiology Department IRCCS Santa Lucia Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"de 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