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Although the functional roles and mechanisms of several lncRNAs have been discovered, a better understanding of the vast majority of lncRNAs remains elusive. To understand the functional roles and mechanisms of lncRNAs is critical because these transcripts represent the majority of the transcriptional output of the mammalian genome. Recent studies have also suggested that lncRNAs are more abundant in the human brain and are involved in neurodevelopment and neurodevelopmental disorders, including autism spectrum disorders (ASDs). In this study, we review several known functions of lncRNAs and the potential contribution of lncRNAs to ASDs and to other genetic syndromes that have a similar clinical presentation to ASDs, such as fragile X syndrome and Rett syndrome.<\/jats:p>","DOI":"10.1111\/cns.12710","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T04:26:37Z","timestamp":1498019197000},"page":"645-656","source":"Crossref","is-referenced-by-count":64,"title":["Long noncoding RNA and its contribution to autism spectrum disorders"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-8444","authenticated-orcid":false,"given":"Jie","family":"Tang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"Department of Preventive Medicine School of Public Health Guangzhou Medical University Xinzao Panyu District Guangzhou 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