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Emerging evidence demonstrates a hippocampus\u2010associated learning and memory deficit in aged<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>4<\/jats:italic>human carriers and also in aged mice carrying human<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>4<\/jats:italic>gene. This suggests that either exogenous<jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>4 or endogenous<jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>4 alters the cognitive profile and hippocampal structure and function. However, little is known regarding how Apoe4 modulates hippocampal dendritic morphology, synaptic function, and neural network activity in young mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this study, we compared hippocampal dendritic and spine morphology and synaptic function of young (4\u00a0months) mice with transgenic expression of the human<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>4<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>3<\/jats:italic>genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hippocampal dendritic and spine morphology and synaptic function were assessed by neuronal imaging and electrophysiological approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morphology results showed that shortened dendritic length and reduced spine density occurred at hippocampal<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 neurons in<jats:italic>Apoe4<\/jats:italic>mice compared to<jats:italic>Apoe3<\/jats:italic>mice. Electrophysiological results demonstrated that in the hippocampal<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 synapses of young<jats:italic>Apoe4<\/jats:italic>mice, basic synaptic transmission, and paired\u2010pulse facilitation were enhanced but long\u2010term potentiation and carbachol\u2010induced hippocampal theta oscillations were impaired compared to young<jats:italic>Apoe3<\/jats:italic>mice. However, both<jats:italic>Apoe<\/jats:italic>genotypes responded similarly to persistent stimulations (4, 10, and 40\u00a0Hz for 4\u00a0seconds).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest significant alterations in hippocampal dendritic structure and synaptic function in<jats:italic>Apoe4<\/jats:italic>mice, even at an early age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12720","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T04:32:21Z","timestamp":1502166741000},"page":"748-758","source":"Crossref","is-referenced-by-count":42,"title":["Hippocampal synaptic and neural network deficits in young mice carrying the human<i><scp>APOE<\/scp>4<\/i>gene"],"prefix":"10.1111","volume":"23","author":[{"given":"Guo\u2010Zhu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Second Hospital of Hebei Medical University Shijiazhuang Hebei China"},{"name":"Department of 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