{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:27:31Z","timestamp":1781332051424,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health Public Health Service","award":["R01\u00a0AA020073 (PN)"],"award-info":[{"award-number":["R01\u00a0AA020073 (PN)"]}]},{"name":"National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical Biological Research","award":["Z1A AA000407 (DML)"],"award-info":[{"award-number":["Z1A AA000407 (DML)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Prenatal alcohol exposure (PAE) is associated with a higher likelihood of developing generalized tonic\u2010clonic seizures (GTCS) in infants and children. However, experimental studies of PAE\u2010related seizures have yielded conflicting results. Here, we investigated the effect of acute PAE on <jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate (NMDA)\u2010induced seizures in developing rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant Sprague Dawley rats were given an oral dose of either ethanol (5\u00a0g\/kg body weight) or vehicle on embryonic day 18. The offspring were tested for susceptibility to NMDA\u2010induced seizures on postnatal day 7 (P7), 21 (P21), 35 (P35), and 42 (P42). Specifically, the prevalence and latency of NMDA\u2010induced continuous wild running\u2010like behaviors (CWR), flexion seizures (FS), wild running seizures (WRS), GTCS, and tonic seizures (TS) were recorded and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate\u2010induced seizures consisted of CWR, FS, GTCS, and TS in &lt;P21 rats, while WRS, GTCS, and TS were observed in &gt;P21 rats. Thus, GTCS were consistently observed during development. PAE significantly increases the prevalence of GTCS in female and male P7\u2010P21 rats and P7\u2010P35 rats, respectively, but not in older rats. PAE also increases the prevalence of TS in male, but not female P21\u2010P35 rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PAE animal model of GTCS may provide a new opportunity to investigate the mechanisms that underlie neuronal hyperexcitability in developing animals prenatally\u2010exposed to alcohol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12756","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T11:03:48Z","timestamp":1504868628000},"page":"808-817","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal alcohol exposure enhances the susceptibility to NMDA\u2010induced generalized tonic\u2010clonic seizures in developing rats"],"prefix":"10.1111","volume":"23","author":[{"given":"Sue J.","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pediatrics Georgetown University Medical Center  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Lovinger","sequence":"additional","affiliation":[{"name":"Laboratory for Integrative Neuroscience Section on Synaptic Pharmacology National Institute on Alcohol Abuse and Alcoholism National Institutes of Health  Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-7292","authenticated-orcid":false,"given":"Prosper","family":"N'Gouemo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Georgetown University Medical Center  Washington DC 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