{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:36:45Z","timestamp":1790534205707,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Summary<\/jats:title>\n \n Aims<\/jats:title>\n \n This open\u2010label prospective phase I\/\n II<\/jats:styled-content>\n a clinical study used autologous bone marrow\u2010derived mesenchymal stromal cells (\n BM<\/jats:styled-content>\n \u2010\n MSC<\/jats:styled-content>\n s) followed by mesenchymal stromal cells conditioned media (\n MSC<\/jats:styled-content>\n \u2010\n CM<\/jats:styled-content>\n ) for the first time to treat multiple sclerosis (\n MS<\/jats:styled-content>\n ) patients. The primary goal was to assess the safety and feasibility and the secondary was efficacy. The correlation between the\n MSC<\/jats:styled-content>\n \u2010\n CM<\/jats:styled-content>\n content and treatment outcome was investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Ten\n MS<\/jats:styled-content>\n patients who failed conventional therapy were enrolled. Adverse events were recorded to assess safety. The Expanded Disability Status Scale (\n EDSS<\/jats:styled-content>\n ) was the primary efficacy measurement, the secondary included clinical (25\n WFT<\/jats:styled-content>\n , 9\u2010\n PHT<\/jats:styled-content>\n ), cognitive (\n MMS<\/jats:styled-content>\n ), ophthalmology (\n OCT<\/jats:styled-content>\n ,\n VEP<\/jats:styled-content>\n ), and radiological (\n MRI<\/jats:styled-content>\n lesion and volume) tests. The\n MSC<\/jats:styled-content>\n s\u2010\n CM<\/jats:styled-content>\n concentration of 27 inflammatory biomarkers was investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The treatment protocol was well tolerated by patients. There was an overall trend of improvement in all the tests, except the lesion volume which increased significantly. A decrease of 4 and 3.5 points on the\n EDSS<\/jats:styled-content>\n was achieved in two patients. We report a correlation between a decreased lesion number at baseline and higher\n IL<\/jats:styled-content>\n \u20106,\n IL<\/jats:styled-content>\n \u20108, and\n VEGF MSC<\/jats:styled-content>\n \u2010\n CM<\/jats:styled-content>\n content.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The used protocol was safe and feasible with possible efficacy. The addition of\n MSC<\/jats:styled-content>\n \u2010\n CM<\/jats:styled-content>\n could be related to the magnitude of\n EDSS<\/jats:styled-content>\n improvement observed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cns.12759","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T14:46:34Z","timestamp":1506696394000},"page":"866-874","source":"Crossref","is-referenced-by-count":118,"title":["Mesenchymal stem cells and conditioned media in the treatment of multiple sclerosis patients: Clinical, ophthalmological and radiological assessments of safety and efficacy"],"prefix":"10.1111","volume":"23","author":[{"given":"Said","family":"Dahbour","sequence":"first","affiliation":[{"name":"Department of Neurology Jordan University Hospital The University of Jordan Amman 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