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The cytosine\u2010adenine\u2010guanine (<jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content>) triplet expansion encoding glutamine present in the protein huntingtin (Htt), produces widespread neuronal and glial pathology. Mutant huntingtin (<jats:styled-content style=\"fixed-case\">mH<\/jats:styled-content>tt) nuclear aggregates are the primary cause of cortical and striatal neuron degeneration, neuronal inflammation, apoptosis and eventual cell loss. The precise mechanisms underlying the pathogenesis of neurodegeneration in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> remain poorly understood and <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients have no current cure. Potassium channels are widely expressed in most cell types. In neurons, they play a crucial role in setting the resting membrane potential, mediating the rapid repolarization phase of the action potential and controlling sub\u2010threshold oscillations of membrane potentials. In glial cells, their major contributions are maintaining the resting membrane potential and buffering extracellular K<jats:sup>+<\/jats:sup>. Thus, potassium channels have an essential function in both physiological and pathological brain conditions. This review summarizes recent progress on potassium channels involved in the pathology of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> by using different <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mouse models. Exploring the dysfunction of potassium channels in the brain illustrates new approaches for targeting this channel for the treatment of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cns.12804","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T19:56:45Z","timestamp":1517255805000},"page":"311-318","source":"Crossref","is-referenced-by-count":36,"title":["Potassium channel dysfunction in neurons and astrocytes in Huntington's disease"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Discipline of Neuroscience and Department of Anatomy and Physiology Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Qing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Ren Ji Hospital Shanghai Jiao Tong University 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