{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:27:16Z","timestamp":1792981636239,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108012"],"award-info":[{"award-number":["81420108012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Multiple evidence has indicated that myelin injury is common in Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). However, whether myelin injury is an early event in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and the relationship between it and cognitive function is still elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Spatial memory of 5<jats:styled-content style=\"fixed-case\">XFAD<\/jats:styled-content> mice was determined by Morris water maze at 1 and 3\u00a0months old. Meanwhile, the deposition of A\u03b2, the expression of myelin basic protein (<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">LINGO<\/jats:styled-content>\u20101, NgR, and myelin ultrastructure in many memory\u2010associated brain regions were detected in one\u2010month\u2010old and three\u2010month\u2010old mice (before and after <jats:styled-content style=\"fixed-case\">LINGO<\/jats:styled-content>\u20101 antibody administration) using immunostaining, Western blot (<jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content>), and transmission electron microscopy (<jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No abnormal A\u03b2 deposition was found in one\u2010month\u2010old 5<jats:styled-content style=\"fixed-case\">XFAD<\/jats:styled-content> mice. However, spatial memory deficits were proved in accordance with an obvious demyelination in memory\u2010associated brain regions in one\u2010month\u2010old mice and both deteriorated with age. Administration of <jats:styled-content style=\"fixed-case\">LINGO<\/jats:styled-content>\u20101 antibody could obviously restore the myelin impairments in <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content> region and partially ameliorate spatial memory deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrated that myelin injury was an early event in 5<jats:styled-content style=\"fixed-case\">XFAD<\/jats:styled-content> mice even prior to emergence of deposition of A\u03b2. Intervention with the <jats:styled-content style=\"fixed-case\">LINGO<\/jats:styled-content>\u20101 antibody could attenuate impaired spatial memory deficits by remyelination, which suggested that myelin injury was involved in spatial memory deficits and remyelination may be a potential therapeutic strategy in early stage of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> or mild cognitive impairments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12809","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T04:26:40Z","timestamp":1518236800000},"page":"381-393","source":"Crossref","is-referenced-by-count":60,"title":["<scp>LINGO<\/scp>\u20101 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5<scp>XFAD<\/scp> mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Di","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated ZhongDa Hospital Neuropsychiatric 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