{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:21:55Z","timestamp":1782156115630,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008474","name":"New Jersey Commission on Brain Injury Research","doi-asserted-by":"publisher","award":["CBIR17PIL012"],"award-info":[{"award-number":["CBIR17PIL012"]}],"id":[{"id":"10.13039\/100008474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03MH109791"],"award-info":[{"award-number":["R03MH109791"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Aims<\/jats:title>This study aimed at understanding the neurobiological mechanisms associated with inattention induced by traumatic brain injury (TBI<\/jats:styled-content>). To eliminate the potential confounding caused by the heterogeneity of TBI<\/jats:styled-content>, we focused on young adults postsports\u2010related concussion (SRC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Functional near\u2010infrared spectroscopy (fNIRS<\/jats:styled-content>) data were collected from 27 young adults post\u2010SRC<\/jats:styled-content> and 27 group\u2010matched normal controls (NC<\/jats:styled-content>s), while performing a visual sustained attention task. Task responsive cortical activation maps and pairwise functional connectivity among six regions of interest were constructed for each subject. Correlations among the brain imaging measures and clinical measures of attention were calculated in each group.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared to the NC<\/jats:styled-content>s, the SRC<\/jats:styled-content> group showed significantly increased brain activation in left middle frontal gyrus (MFG<\/jats:styled-content>) and increased functional connectivity between right inferior occipital cortex (IOC<\/jats:styled-content>) bilateral calcarine gyri (CG<\/jats:styled-content>). The left MFG<\/jats:styled-content> activation magnitude was significantly negatively correlated with the hyperactive\/impulsive symptom severity measure in the NC<\/jats:styled-content>s, but not in the patients. The right hemisphere CG<\/jats:styled-content>\u2010IOC<\/jats:styled-content> functional connectivity showed a significant positive correlation with the hyperactive\/impulsive symptom severity measure in patients, but not in NC<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The current data suggest that abnormal left MFG<\/jats:styled-content> activation and hyper\u2010communications between right IOC<\/jats:styled-content> and bilateral CG<\/jats:styled-content> during visual attention processing may significantly contribute to behavioral manifestations of attention deficits in patients with TBI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12811","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T04:18:53Z","timestamp":1516681133000},"page":"539-548","source":"Crossref","is-referenced-by-count":37,"title":["Altered cortical activation and connectivity patterns for visual attention processing in young adults post\u2010traumatic brain injury: A functional near infrared spectroscopy study"],"prefix":"10.1111","volume":"24","author":[{"given":"Ziyan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering New Jersey Institute of Technology Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Mazzola","sequence":"additional","affiliation":[{"name":"New Jersey Pediatric Neuroscience Institute Morristown NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Catania","sequence":"additional","affiliation":[{"name":"North Jersey Neurodevelopmental Center North Haledon NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyindamola","family":"Owoeye","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering New Jersey Institute of Technology Newark NJ 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