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Functional connectivity analyses were performed between four predefined seeds (dorsal anterior cingulate cortex, rostral anterior cingulate cortex, posterior insula, and prefrontal cortex), and the whole brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall interpretation was that there were differences between the effects of oxycodone and venlafaxine on functional connectivity. Oxycodone mainly showed decreased functional connectivity between limbic structures and to supralimbic areas (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Venlafaxine also showed decreased functional connectivity between limbic structures and to supralimbic areas, but increased functional connectivity to structures in the midbrain and brain stem was also found (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oxycodone and venlafaxine showed differential effects on resting\u2010state functional connectivity as compared to placebo. This supports that the two drugs exert different mechanisms, and that the drugs in combination may exert additive effects and could potentially improve pain therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12827","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T04:42:40Z","timestamp":1519274560000},"page":"820-827","source":"Crossref","is-referenced-by-count":12,"title":["Differential effects of oxycodone and venlafaxine on resting state functional connectivity\u2014A randomized placebo\u2010controlled magnetic resonance imaging study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-5519","authenticated-orcid":false,"given":"Tine M.","family":"Hansen","sequence":"first","affiliation":[{"name":"Mech\u2010Sense Department of Radiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Lelic","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens B.","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Radiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71522-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.126.117"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:18:1-2:143"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.84454"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21265"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114548436"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044799"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12345"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(88)90184-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.10.033"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0439-05.2005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_8_14_1","unstructured":"BrettM AntonJ ValabregueR PolineJ.Presented at the 8th International Conference on Functional Mapping of the Human Brain June 2\u20136 2002 Sendai Japan. 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