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The focus is on data derived from recording of electrophysiological signals in behaving transgenic mouse models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussions<\/jats:title><jats:p>Firing patterns of individual neurons and the frequency oscillations of local field potentials indicate a disruption in corticostriatal processing driven, in large part, by interactions between cells that contain the mutant gene rather than the mutant gene alone. Dysregulation of glutamate, an excitatory amino acid released by cortical afferents, plays a key role in the breakdown of corticostriatal communication, a process modulated by ascorbate, an antioxidant vitamin found in high concentration in striatum. Up\u2010regulation of glutamate transport by drug administration or viral\u2010vector delivery improves ascorbate homeostasis and neurobehavioral processing in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> mice. Further analysis of electrophysiological data, including the use of sophisticated computational strategies, is required to discern how behavioral demands modulate the flow of corticostriatal information and its disruption by <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long before massive cell loss occurs, <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> impairs the mechanisms by which cortical and striatal neurons communicate. A key problem identified in transgenic animal models is dysregulation of the dynamic changes in extracellular glutamate and ascorbate. Improved understanding of how these neurochemical systems impact corticostriatal communication is necessary before an effective therapeutic strategy can emerge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12828","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:10:01Z","timestamp":1519243801000},"page":"281-291","source":"Crossref","is-referenced-by-count":36,"title":["Corticostriatal network dysfunction in Huntington's disease: Deficits in neural processing, glutamate transport, and ascorbate release"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-7796","authenticated-orcid":false,"given":"George V.","family":"Rebec","sequence":"first","affiliation":[{"name":"Program in Neuroscience Department of Psychological and Brain Sciences Indiana University  Bloomington IN 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