{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:44:22Z","timestamp":1790631862434,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571257"],"award-info":[{"award-number":["81571257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771179"],"award-info":[{"award-number":["81771179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2015J01398"],"award-info":[{"award-number":["2015J01398"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2015J05154"],"award-info":[{"award-number":["2015J05154"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>To investigate changes in the functional connectivity (FC<\/jats:styled-content>) pattern in the posterior cingulate cortex (PCC<\/jats:styled-content>) of Parkinson's disease (PD<\/jats:styled-content>) patients with mild cognitive impairment and dementia by employing resting\u2010state functional magnetic resonance imaging (RS<\/jats:styled-content>\u2010fMRI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010seven PD<\/jats:styled-content> patients with different cognitive status and 9 healthy control subjects (control group) were enrolled for RS<\/jats:styled-content>\u2010fMRI<\/jats:styled-content>. The RS<\/jats:styled-content>\u2010fMRI<\/jats:styled-content> data were analyzed with DPARSF<\/jats:styled-content> and REST<\/jats:styled-content> software. Regions with changed functional connectivity were determined by the seed\u2010based voxelwise method and compared between groups. Correlation between the intensity of FC<\/jats:styled-content> and the MoCA<\/jats:styled-content> scores of PD<\/jats:styled-content> group was analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Parametric maps showed statistical increases in PCC<\/jats:styled-content> functional connectivity in PD<\/jats:styled-content>\u2010MCI<\/jats:styled-content> patients and decreases in PCC<\/jats:styled-content> connectivity in PDD<\/jats:styled-content> patients. The latter group of patients also showed evidence for increased connectivity between prefrontal cortices and posterior cerebellum. A significant positive correlation was found between the MoCA<\/jats:styled-content> scores and the strength of PCC<\/jats:styled-content> connectivity in the angular gyrus and posterior cerebellum and a negative correlation between MoCA<\/jats:styled-content> scores and PCC<\/jats:styled-content> connectivity in all other brain regions.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>When patients transition from PD<\/jats:styled-content>\u2010NCI<\/jats:styled-content> to PD<\/jats:styled-content>\u2010MCI<\/jats:styled-content>, there appears to be an increase in functional connectivity in the PCC<\/jats:styled-content>, suggesting an expansion of the cortical network. Another new network (a compensatory prefrontal cortical\u2010cerebellar loop) later develops during the transition from PD<\/jats:styled-content>\u2010MCI<\/jats:styled-content> to PDD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.12838","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T18:52:40Z","timestamp":1520103160000},"page":"897-905","source":"Crossref","is-referenced-by-count":63,"title":["Abnormal resting\u2010state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhou\u2010Wei","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Neurology Fujian Institute of Geriatrics Fujian Medical University Union Hospital Fuzhou China"},{"name":"Department of Medical Oncology Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Fuzhou 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