{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:05:34Z","timestamp":1790402734978,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007359","name":"Fondazione Banco di Sardegna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013003","name":"Universit\u00e0 degli Studi di Cagliari","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Prenatal maternal immune activation (MIA) is associated with a risk to develop schizophrenia and affects dopamine systems in the ventral tegmental area (VTA), key region in the neurobiology of psychoses. Considering the well\u2010described sex differences in schizophrenia, we investigated whether sex affects MIA impact on dopamine system and on schizophrenia\u2010related behavioral phenotype. Furthermore, considering peroxisome proliferator\u2010activated receptor\u2010\u03b1 (PPAR\u03b1) expression in the CNS as well as its anti\u2010inflammatory and neuroprotective properties, we tested if PPAR\u03b1 activation by prenatal treatment with a clinically available fibrate (fenofibrate) may mitigate MIA\u2010related effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We induced MIA in rat dams with polyriboinosinic\u2010polyribocytidylic acid (Poly I:C) and assessed prepulse inhibition and dopamine neuron activity in the VTA by means of electrophysiological recordings in male and female preweaned and adult offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Poly I:C\u2010treated males displayed prepulse inhibition deficits, reduced number and firing rate of VTA dopamine neurons, and paired\u2010pulse facilitation of inhibitory and excitatory synapses. Prenatal fenofibrate administration attenuated detrimental effects induced by MIA on both the schizophrenia\u2010like behavioral phenotype and dopamine transmission in male offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study confirms previous evidence that females are less susceptible to MIA and highlights PPAR\u03b1 as a potential target for treatments in schizophrenia<jats:italic>.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13087","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T13:43:05Z","timestamp":1542807785000},"page":"549-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The PPAR\u03b1 agonist fenofibrate attenuates disruption of dopamine function in a maternal immune activation rat model of schizophrenia"],"prefix":"10.1111","volume":"25","author":[{"given":"Marta","family":"De Felice","sequence":"first","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-8651","authenticated-orcid":false,"given":"Miriam","family":"Melis","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Aroni","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lisa","family":"Muntoni","sequence":"additional","affiliation":[{"name":"Section of Cagliari Neuroscience Institute, National Research Council of Italy (CNR) Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Fanni","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Frau","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Devoto","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-3205","authenticated-orcid":false,"given":"Marco","family":"Pistis","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences University of Cagliari Monserrato Italy"},{"name":"Section of Cagliari Neuroscience Institute, National Research Council of Italy (CNR) Monserrato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318212c196"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300248"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.03.2104"},{"issue":"6","key":"e_1_2_7_5_1","first-page":"761","article-title":"Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort","volume":"155","author":"Abi\u2010Dargham A","year":"1998","journal-title":"AJ Psychiatry"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.14.8104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9235"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.10"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00125-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.03.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.129"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.02.022"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.07.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710790980014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13668"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450111314070002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.182"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyw007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5408-09.2010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.44"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3221-08.2008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.04.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1309-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.09.014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.031"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.05.010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0012-07.2007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-02-00796.1997"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950020063007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.04.044"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10882-014-9397-x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90010-V"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903230212"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-05-01325.1991"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(89)90019-1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90070-1"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000290040"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.013"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.80"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2009.01856.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.031"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009206"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.09.032"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.10.004"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.011"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527311312010012"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2017.03.008"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.08.064"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106908200"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2015.1092944"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13863"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064541"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.07.024"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.09.002"},{"issue":"7","key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1128\/IAI.67.7.3488-3493.1999","article-title":"Effect of peroxisome proliferator\u2010activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia","volume":"67","author":"Hill MR","year":"1999","journal-title":"Infect Immun"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.04.003"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300562200"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820755b5"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q626"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1989.tb00648.x"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.13087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:02:35Z","timestamp":1694343755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,21]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/cns.13087"],"URL":"https:\/\/doi.org\/10.1111\/cns.13087","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,21]]},"assertion":[{"value":"2018-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}