{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:10:43Z","timestamp":1791389443809,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine whether the velocity of saccadic eye movements in internuclear ophthalmoparesis (<jats:styled-content style=\"fixed-case\">INO<\/jats:styled-content>) improves with fampridine treatment in patients with multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized, double\u2010blind, placebo\u2010controlled, cross\u2010over trial with fampridine in patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">INO<\/jats:styled-content>. Horizontal saccades were recorded at baseline and at multiple time points post\u2010dose. Main outcome measures were the change of peak velocity versional dysconjugacy index (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content>) and first\u2010pass amplitude <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content>). Both parameters were compared between fampridine and placebo using a mixed model analysis of variance taking patients as their own control. Pharmacokinetics was determined by serial blood sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients had a bilateral and 10 had a unilateral <jats:styled-content style=\"fixed-case\">INO<\/jats:styled-content>. One patient had an <jats:styled-content style=\"fixed-case\">INO<\/jats:styled-content> of abduction (posterior <jats:styled-content style=\"fixed-case\">INO<\/jats:styled-content> of Lutz) and was excluded. Fampridine significantly reduced both <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> (\u221217.4%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u221222.4%, \u221212.1%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and <jats:styled-content style=\"fixed-case\">FPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> (\u221212.5%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u221218.9%, \u22125.5%; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). Pharmacokinetics demonstrated that testing coincided with the average <jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> at 2.08\u00a0hours (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 45\u00a0minutes). The main adverse event reported after administration of fampridine was dizziness (61%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fampridine improves saccadic eye movements due to <jats:styled-content style=\"fixed-case\">INO<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Treatment response to fampridine may gauge patient selection for inclusion to remyelination strategies in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> using saccadic eye movements as primary outcome measure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13096","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T06:47:41Z","timestamp":1550040461000},"page":"697-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double\u2010blind, placebo\u2010controlled cross\u2010over trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-6467","authenticated-orcid":false,"given":"Kawita M. S.","family":"Kanhai","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny A.","family":"Nij Bijvank","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Neuro\u2010ophthalmology Expertise Center Amsterdam UMC Amsterdam the Netherlands"},{"name":"Department of Neurology MS Center and Neuro\u2010ophthalmology Expertise Center Amsterdam UMC Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorick L.","family":"Wagenaar","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KyoungSoo","family":"Lim","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden the Netherlands"},{"name":"KCRN Research Germantown Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrin C.","family":"Bergheanu","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Petzold","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Neuro\u2010ophthalmology Expertise Center Amsterdam UMC Amsterdam the Netherlands"},{"name":"Department of Neurology MS Center and Neuro\u2010ophthalmology Expertise Center Amsterdam UMC Amsterdam the Netherlands"},{"name":"The National Hospital for Neurology and Neurosurgery Queen Square and Moorfields Eye Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Verma","sequence":"additional","affiliation":[{"name":"Experimental Medicine Biogen Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hesterman","sequence":"additional","affiliation":[{"name":"inviCRO Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike P.","family":"Wattjes","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard M. 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