{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:32:14Z","timestamp":1761514334118,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Irritability has been described as a frequent adverse event in patients affected by epilepsy and treated with perampanel (PER), levetiracetam (LEV), and less frequently with valproic acid (VPA). Since the questionnaire for irritability (I\u2010EPI) is a validated instrument to measure this psychiatric manifestation in patients affected by epilepsy, in this study we aimed at investigating the effect of PER as first add\u2010on therapy on I\u2010EPI. Moreover, we compared the effectiveness and I\u2010EPI scores obtained at 12\u2010month follow\u2010up visits in patients treated by PER, LEV, or VPA in order to measure irritability as a consequence of these treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data from 17 patients treated by PER, 16 patients treated by LEV, and 16 patients under VPA treatment followed for 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not document significant changes of I\u2010EPI questionnaire between baseline and follow\u2010up in the PER group. As concerning the comparison of I\u2010EPI among PER, LEV, and VPA groups, we documented lower global scores in PER than both LEV (<jats:italic>P<\/jats:italic>&lt; 0.05) and VPA (<jats:italic>P<\/jats:italic>&lt; 0.05) groups. Moreover, patients under PER treatment showed lower scores than LEV and VPA (<jats:italic>P<\/jats:italic>&lt; 0.05) in I\u2010EPI items measuring the gentle personality, anxiety of having epileptic seizures in front of others, and irritability in thinking that they can have an epileptic seizure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This retrospective study described a stable and possibly lower degree of irritability in patients starting PER than LEV and VPA treatments, although we documented the comparable effectiveness of PER, LEV, and VPA as first add\u2010on treatments in patients affected by uncontrolled epileptic seizures. However, the small sample of patients included in this study and the absence of I\u2010EPI scores obtained at baseline visits in LEV and VPA groups require further investigations to confirm this preliminary evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13098","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T19:44:50Z","timestamp":1548359090000},"page":"632-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add\u2010on therapy compared to levetiracetam and valproic acid"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-1332","authenticated-orcid":false,"given":"Claudio","family":"Liguori","sequence":"first","affiliation":[{"name":"Epilepsy Centre Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Turner","sequence":"additional","affiliation":[{"name":"Epilepsy Centre San Paolo Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Izzi","sequence":"additional","affiliation":[{"name":"Epilepsy Centre Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Assogna","sequence":"additional","affiliation":[{"name":"Epilepsy Centre Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria P.","family":"Canevini","sequence":"additional","affiliation":[{"name":"Epilepsy Centre San Paolo Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola B.","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Epilepsy Centre Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS Fondazione Santa Lucia Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[{"name":"Epilepsy Centre Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2018.02.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2014.10.3.175"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(92)90222-B"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.04.051"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.08.039"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.08.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00684.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.11.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2015.1091303"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.09.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12492"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12529"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00410-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00314-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13054"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.06.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.09.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520150039018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S60089"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.01.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.04.017"},{"issue":"4","key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"From the commission on classification and terminology of the international league against epilepsy","volume":"22","author":"Proposal for revised clinical and electroencephalographic classification of epileptic seizures","year":"1981","journal-title":"Epilepsia"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.09.028"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.09.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1392509"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.08.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/ebeh.2000.0050"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.09.072"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.10.017"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.13098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T09:27:27Z","timestamp":1720949247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/cns.13098"],"URL":"https:\/\/doi.org\/10.1111\/cns.13098","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"type":"print","value":"1755-5930"},{"type":"electronic","value":"1755-5949"}],"subject":[],"published":{"date-parts":[[2019,1,23]]},"assertion":[{"value":"2018-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}