{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:53:22Z","timestamp":1782269602398,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018R1A2B2007714"],"award-info":[{"award-number":["NRF\u20102018R1A2B2007714"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three \u03bc\u2010opioid receptor gene (<jats:italic>OPRM1<\/jats:italic>) variants and two \u03ba\u2010opioid receptor gene (<jats:italic>OPRK1<\/jats:italic>) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop\u2010signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS\u201011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, <jats:italic>OPRK1<\/jats:italic> SNP rs6473797 was significantly related to the severity of alcohol\u2010related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, <jats:italic>OPRM1<\/jats:italic> SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS\u201011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13138","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T04:02:14Z","timestamp":1555732934000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population"],"prefix":"10.1111","volume":"26","author":[{"given":"Chun Il","family":"Park","sequence":"first","affiliation":[{"name":"Institute of Behavioral Science in Medicine Yonsei University College of 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