{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:27:23Z","timestamp":1771478843704,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172245"],"award-info":[{"award-number":["7172245"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Development","doi-asserted-by":"publisher","award":["CFMD:2016-2-4113"],"award-info":[{"award-number":["CFMD:2016-2-4113"]}],"id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81761148026"],"award-info":[{"award-number":["81761148026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873802"],"award-info":[{"award-number":["81873802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571340"],"award-info":[{"award-number":["81571340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Functional brain abnormalities, including altered cerebral perfusion and functional connectivities, have been illustrated in adults with attention\u2010deficit\/hyperactivity disorder (aADHD). The present study attempted to explore the alterations of cerebral blood flow (CBF) and resting\u2010state functional connectivity (RSFC) simultaneously to understand the neural mechanisms for adults with ADHD comprehensively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting\u2010state arterial spin labeling (ASL) and blood oxygenation level\u2010dependent (BOLD) magnetic resonance imaging (MRI) data were acquired for 69 male aADHD and 69 matched healthy controls (HCs). The altered CBFs associated with aADHD were explored based on both categorical (aADHD vs HCs) and dimensional (correlation with aADHD core symptoms) perspectives. Then, the seed\u2010based RSFC analyses were developed for the regions showing significant alterations of CBF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly decreased CBF in the large\u2010scale resting\u2010state networks regions (eg, ventral attentional network, somatomotor network, limbic network) and subcortical regions was indicated in aADHD compared with HCs. The correlation analyses indicated that the hypoperfusion in left putamen\/global pallidum and left amygdala\/hippocampus was correlated with ADHD inattentive and total symptoms, respectively. Further, weaker negative functional connectivity between left amygdala and bilateral supplementary motor area, bilateral superior frontal gyrus, and left medial frontal gyrus was found in adults with ADHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings suggested alterations of both cerebral perfusion and functional connectivity for the left amygdala in aADHD. The combination of CBF and RSFCs may help to interpret the neuropathogenesis of ADHD more comprehensively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13185","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T04:24:08Z","timestamp":1561350248000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Alterations of cerebral perfusion and functional brain connectivity in medication\u2010na\u00efve male adults with attention\u2010deficit\/hyperactivity disorder"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-5477","authenticated-orcid":false,"given":"Ya\u2010Wen","family":"Tan","sequence":"first","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Rong","family":"Pan","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China"},{"name":"Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu\u2010Hong","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Systems Science Beijing Normal University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu\u2010Jin","family":"Qian","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health Beijing China"},{"name":"National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) &amp; the NHC Key Laboratory of Mental Health (Peking University) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,23]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: Text Revision","author":"APA","year":"2000"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30032-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054715604360"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14101266"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-006-1005-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2014.907526"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.01.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010459107"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.3.3.031411"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318219b49d"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090168"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.278"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-002-0384-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2010.11.092"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002142-200402000-00003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.212"},{"key":"e_1_2_8_20_1","first-page":"818456","article-title":"Arterial spin labeling (ASL) fMRI: advantages, theoretical constrains, and experimental challenges in neurosciences","volume":"2012","author":"Borogovac A","year":"2012","journal-title":"Int J Biomed Imaging"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1017"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.169"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.11.021"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121757"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214900110"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160201"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.11.009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.175056"},{"key":"e_1_2_8_30_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u00ae Axis I Disorders (SCID\u2010I), Clinical Version","author":"First M","year":"1996"},{"key":"e_1_2_8_31_1","volume-title":"Conner\u2019s Adult ADHD Diagnostic Interview for DSM\u2010IV:CAADID[EB\/OL]","author":"Epstein J"},{"key":"e_1_2_8_32_1","volume-title":"ADHD Rating Scale\u2010IV: Checklists, Norms, and Clinical Interpretation","author":"DuPaul G","year":"1998"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23737"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.07.003"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602413113"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054716661419"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20067"},{"issue":"1","key":"e_1_2_8_41_1","first-page":"S3","article-title":"Brain abnormalities in attention\u2010deficit hyperactivity disorder: a review","volume":"58","author":"Rubia K","year":"2014","journal-title":"Rev Neurol"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2018.04.002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200112000-00009"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1067"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(99)00055-X"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2017.09.004"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9881-5"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9470-9"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.07.010"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.12.021"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.296"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.069"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2016.57.223"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.03.008"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.10.006"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3272-12.2012"},{"issue":"6","key":"e_1_2_8_57_1","first-page":"509","article-title":"Hippocampus and amygdala morphology in adults with attention\u2010deficit hyperactivity disorder","volume":"33","author":"Perlov E","year":"2008","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070966"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540260902962156"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07071145"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.03.004"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.07.008"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12899"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.04.031"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000200"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1570-0"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23976"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000031"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.13185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:14:29Z","timestamp":1694092469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,23]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/cns.13185"],"URL":"https:\/\/doi.org\/10.1111\/cns.13185","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,23]]},"assertion":[{"value":"2019-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}