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Despite the significant effect of RH on hippocampal function, the underlying mechanisms are currently unknown. Our goal was to determine the effect of RH exposure on hippocampal metabolism in treated streptozotocin\u2010diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hyperglycemia was corrected by insulin pellet implantation. Insulin\u2010treated diabetic (ITD) rats were exposed to mild\/moderate RH once a day for 5 consecutive days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effect of RH on hippocampal metabolism revealed 65 significantly altered metabolites in the RH group compared with controls. Several significant differences in metabolite levels belonging to major pathways (eg, Krebs cycle, gluconeogenesis, and amino acid metabolism) were discovered in RH\u2010exposed ITD rats when compared to a control group. Key glycolytic enzymes including hexokinase, phosphofructokinase, and pyruvate kinase were affected by RH exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate that the exposure to RH leads to metabolomics alterations in the hippocampus of insulin\u2010treated streptozotocin\u2010diabetic rats. Understanding how RH affects hippocampal metabolism may help attenuate the adverse effects of RH on hippocampal functions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13186","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T03:44:03Z","timestamp":1562557443000},"page":"126-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin\u2010induced diabetic rats"],"prefix":"10.1111","volume":"26","author":[{"given":"Neelesh","family":"Dewan","sequence":"first","affiliation":[{"name":"Peritz Scheinberg Cerebral Vascular Disease Research Laboratories University of Miami School of Medicine Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Shukla","sequence":"additional","affiliation":[{"name":"Peritz Scheinberg Cerebral Vascular Disease Research Laboratories University of Miami School of Medicine Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish K.","family":"Rehni","sequence":"additional","affiliation":[{"name":"Peritz Scheinberg Cerebral Vascular Disease Research Laboratories University of Miami School of Medicine Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin B.","family":"Koronowski","sequence":"additional","affiliation":[{"name":"Peritz Scheinberg Cerebral Vascular Disease Research Laboratories University of Miami School of Medicine Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"},{"name":"Neuroscience Program University of Miami School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle D.","family":"Klingbeil","sequence":"additional","affiliation":[{"name":"Peritz Scheinberg Cerebral Vascular Disease Research Laboratories University of Miami School of Medicine Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Stradecki\u2010Cohan","sequence":"additional","affiliation":[{"name":"Peritz Scheinberg Cerebral Vascular Disease Research Laboratories University of Miami School of Medicine Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"},{"name":"Neuroscience Program University of Miami School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Southeast Center for Integrated Metabolomics, Clinical and Translational Science Institute University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami School of Medicine Miami Florida USA"},{"name":"Evelyn F. 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