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However, the pathological underpinning is not fully known. We aimed to explore the critical structural alterations in the process of cognitive decline and its relationships with the dopaminergic deficit and the level of related cerebrospinal fluid (CSF) proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010four patients with PD and 32 controls were included in this study. Neuropsychological tests were performed at baseline and after 28\u00a0months to identify which patients had normal cognition and which ones developed PD\u2010MCI after follow\u2010up (\u201cconverters\u201d). Gray matter atrophy was assessed in cross\u2010sectional and longitudinal analyses, respectively. The associations between altered GMV with dopamine transporter (DAT) results and the level of CSF proteins were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 94 patients with normal cognition at baseline, 24 (mean age, 63.1\u00a0years) developed PD\u2010MCI after 28\u00a0months of follow\u2010up, and 70 (mean age, 62.3\u00a0years) remained nonconverters. The converters showed significant right temporal atrophy at baseline and extensive atrophy in temporal lobe at follow\u2010up. Progressive bilateral frontal lobe atrophy was found in the converters. Baseline right temporal atrophy was correlated with the striatal dopaminergic degeneration in the converters. No correlation was found between the right temporal atrophy and the alterations of CSF proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early atrophy in temporal lobes and progressive atrophy in frontal lobes might be a biomarker for developing multidomain impairment of cognition and converting to PD\u2010MCI. Furthermore, cognition\u2010related temporal atrophy might be associated with dopaminergic deficit reflected by DAT scan but independent of CSF proteins in patients with PD who convert to PD\u2010MCI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13188","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T11:07:52Z","timestamp":1562411272000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Progressive brain atrophy in Parkinson's disease patients who convert to mild cognitive impairment"],"prefix":"10.1111","volume":"26","author":[{"given":"Cheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of 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