{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:19:34Z","timestamp":1792289974584,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004319","name":"Shin Kong Wu Ho-Su Memorial Hospital","doi-asserted-by":"publisher","award":["SKH-8302-104-DR-16"],"award-info":[{"award-number":["SKH-8302-104-DR-16"]}],"id":[{"id":"10.13039\/501100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004319","name":"Shin Kong Wu Ho-Su Memorial Hospital","doi-asserted-by":"publisher","award":["2019SKHADR016"],"award-info":[{"award-number":["2019SKHADR016"]}],"id":[{"id":"10.13039\/501100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Nonmotor symptoms (NMS) such as cognitive impairment and impulse\u2010control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham\u2010controlled, crossover study, we aimed to explore the single\u2010session tDCS effects on cognitive performance in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20\u00a0minutes of either 2\u00a0mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go\/no\u2010go tasks. Performance of the tasks was compared between the two conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Single\u2010session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single\u2010session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13210","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T10:19:59Z","timestamp":1566209999000},"page":"1237-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of single\u2010session transcranial direct current stimulation on cognition in Parkinson's disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-2234","authenticated-orcid":false,"given":"Chi\u2010ieong","family":"Lau","sequence":"first","affiliation":[{"name":"Dementia Center, Department of Neurology Shin Kong Wu Ho\u2010Su Memorial Hospital Taipei Taiwan"},{"name":"Applied Cognitive Neuroscience Group, Institute of Cognitive Neuroscience University College London London UK"},{"name":"College of Medicine Fu\u2010Jen Catholic University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu\u2010N","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Brain Science National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Psychiatry Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Neurology, Memory and Aging Centre University of California, San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae\u2010Chwen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei Taiwan"},{"name":"Endeavor Rehabilitation Clinic Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shin Kong Wu Ho-Su Memorial Hospital Taipei 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