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Neurotrophic factors such as BDNF stimulate neurite outgrowth and protect axotomized neurons. Can the effects obtained by neutralizing Nogo\u2010A, inducing an environment favorable for axonal sprouting, be strengthened by adding BDNF? A unilateral incomplete hemicord lesion at C7 level interrupted the main corticospinal component in three groups of adult macaque monkeys: control monkeys (n\u00a0=\u00a06), anti\u2010Nogo\u2010A antibody\u2010treated monkeys (n\u00a0=\u00a07), and anti\u2010Nogo\u2010A antibody and BDNF\u2010treated monkeys (n\u00a0=\u00a05). The functional recovery of manual dexterity was significantly different between the 3 groups of monkeys, the lowest in the control group. Whereas the anti\u2010Nogo\u2010A antibody\u2010treated animals returned to manual dexterity performances close to prelesion ones, irrespective of lesion size, both the control and the anti\u2010Nogo\u2010A\/BDNF animals presented a limited functional recovery. In the control group, the limited spontaneous functional recovery depended on lesion size, a dependence absent in the combined treatment group (anti\u2010Nogo\u2010A antibody and BDNF). The functional recovery in the latter group was significantly lower than in anti\u2010Nogo\u2010A antibody\u2010treated monkeys, although the lesion was larger in three out of the five monkeys in the combined treatment group.<\/jats:p>","DOI":"10.1111\/cns.13213","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:27:42Z","timestamp":1565958462000},"page":"260-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combined with anti\u2010Nogo\u2010A antibody treatment, BDNF did not compensate the extra deleterious motor effect caused by large size cervical cord hemisection in adult macaques"],"prefix":"10.1111","volume":"26","author":[{"given":"Marie\u2010Laure","family":"Beaud","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine University of Fribourg Fribourg 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