{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:05:19Z","timestamp":1758474319476,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY17H090005"],"award-info":[{"award-number":["LY17H090005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81520108010","81771216"],"award-info":[{"award-number":["81520108010","81771216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate potential genetic overlap between essential tremor and Parkinson's disease in a cohort of 825 subjects from an Eastern Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect three essential tremor\u2010related single nucleotide polymorphisms. Odds ratio (OR) and 95% confidential interval (CI) were calculated to assess the relationship between polymorphisms and Parkinson's disease susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results demonstrated that the odds ratios of rs3794087 of SLC1A2, rs9652490 of LINGO1, and rs17590046 of PPARGC1A were 0.71 (95% CI\u00a0=\u00a00.55\u20100.91), 0.99 (95% CI\u00a0=\u00a00.78\u20101.26), and 0.88 (95% CI\u00a0=\u00a00.62\u20101.25), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An essential tremor SNP (rs3794087 of SLC1A2) is associated with a decreased risk of PD in the Eastern Han Chinese population, while rs9652490 (<jats:italic>LINGO1<\/jats:italic>) and rs17590046 (<jats:italic>PPARGC1A<\/jats:italic>) do not show an association.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13272","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T06:10:20Z","timestamp":1574403020000},"page":"448-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China"],"prefix":"10.1111","volume":"26","author":[{"given":"Ting","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Neurology College of Medicine Second Affiliated Hospital Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine Second Affiliated Hospital Zhejiang University Hangzhou 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