{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:40:02Z","timestamp":1773351602966,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,8]],"date-time":"2019-12-08T00:00:00Z","timestamp":1575763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["2017YFC1308401"],"award-info":[{"award-number":["2017YFC1308401"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study investigated the safety and efficacy of remote ischemic conditioning (RIC) on ameliorating the sequelae of ischemic moyamoya disease (iMMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 iMMD patients underwent long\u2010term RIC and were followed up at 0.5, 1, and 2\u00a0years for clinical outcomes, including frequency of stroke recurrence, Patient Global Impression of Change (PGIC) scale, peak systolic velocities (PSV), and cerebral perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the whole RIC treatment process, no RIC\u2010related adverse event occurred. Only one of 30 patients suffered a onetime infarction (3.3%), and the ratios of acceptable PGIC were 88.2%, 64.3%, and 92.3% at 0.5, 1, and 2\u00a0years follow\u2010up. Kaplan\u2010Meier analysis showed the frequency of stroke recurrence was significantly reduced after RIC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.013). The frequency of TIA per week was 1.1 (0.6, 2.8) prior to RIC and 0.1 (0.0, 0.5) post\u2010RIC (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Compared to baseline, PSV values were significantly reduced after RIC treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002 at 0.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.331 at 1, and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006 at 2\u00a0years). In patients undergoing perfusion studies, 75% obtained improvement on followed\u2010up SPECT and 95% on followed\u2010up PET maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Remote ischemic conditioning may be beneficial on controlling iMMD\u2010induced ischemic events, relieving symptoms, and improving cerebral perfusion, without incidence of complications in this case series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13279","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T04:39:11Z","timestamp":1575866351000},"page":"549-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Remote ischemic conditioning for the treatment of ischemic moyamoya disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-2187","authenticated-orcid":false,"given":"Jia\u2010yue","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Department of China\u2010America Institute of Neuroscience Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010ling","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Tangshan Union Medical College Hospital Tangshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010shan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Weifang People's Hospital Wenfang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-4863","authenticated-orcid":false,"given":"Karam","family":"Asmaro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Neurosurgery Henry Ford Health System Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Department of China\u2010America Institute of Neuroscience Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of China\u2010America Institute of Neuroscience Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010chuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of China\u2010America Institute of Neuroscience Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Department of Neurosurgery Wayne State University School of Medicine Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2744","authenticated-orcid":false,"given":"Xun\u2010ming","family":"Ji","sequence":"additional","affiliation":[{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Department of China\u2010America Institute of Neuroscience Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-8758","authenticated-orcid":false,"given":"Ran","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders Beijing China"},{"name":"Department of China\u2010America Institute of Neuroscience Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018563"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.04.083"},{"issue":"4","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1227\/NEU.0b013e318208f1da","article-title":"Significance of focal cerebral hyperperfusion as a cause of transient neurologic deterioration after extracranial\u2010intracranial bypass for moyamoya disease: comparative study with non\u2010moyamoya patients using N\u2010isopropyl\u2010p\u2010[(123)I]iodoamphetamine single\u2010photon emission computed tomography","volume":"68","author":"Fujimura M","year":"2011","journal-title":"Neurosurgery"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.654723"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101527"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.691"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101764"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001346"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318271f76a"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0358-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.245"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132814Y.0000000351"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2003.11.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000259712.64772.85"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12702"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2018.10.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2018.07.022"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-018-0994-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12130"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.11.JNS161688"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.8.JNS152875"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.11.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-018-0511-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.06.076"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.4.JNS081649"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12780"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.02.046"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1177\/0271678X18757621","article-title":"Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease","volume":"38","author":"Sato S","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000135"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17732884"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.13279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T16:06:33Z","timestamp":1694016393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,8]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/cns.13279"],"URL":"https:\/\/doi.org\/10.1111\/cns.13279","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,8]]},"assertion":[{"value":"2019-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}