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High\u2010frequency 10\u00a0kHz spinal cord stimulation (10\u00a0kHz SCS) has been shown to provide paresthesia\u2010free pain relief for a wide variety of pain indications. This article summarizes the current and emerging data as they relate to the clinical use of the therapy in various pain syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted using the PubMed electronic database using keywords related to 10\u00a0kHz SCS. The database was queried from 2013 to May 2019. Articles reporting clinical studies that included human subjects permanently treated with 10\u00a0kHz SCS (Senza\u00ae system) were included in the review. Recent and relevant conference proceedings known to the authors were also included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The selected literature demonstrated significant evidence for the efficacy of 10\u00a0kHz SCS in treating chronic back and leg pain (CBLP), including a randomized, controlled trial as well as prospective and retrospective studies. One\u2010year follow\u2010up responder rates (pain relief\u00a0\u226550%) ranged from 60% to 80%. Other studies and case series showed promising outcomes in specific conditions, including nonsurgical refractory back pain, neuropathic limb pain, complex regional pain syndrome, chronic widespread pain, chronic pelvic pain, and intractable headache. Subgroup analyses also pointed toward the potential of 10\u00a0kHz SCS being successful when low\u2010frequency SCS has failed. The vast majority of these studies reported improved quality of life (QOL) metrics and\/or reduced opioid consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Level I evidence already exists for the efficacy of 10\u00a0kHz SCS in treating CBLP, supported by real\u2010world clinical experience. Other studies demonstrate the potential of the therapy across a range of chronic pain etiologies, although larger confirmatory studies are recommended. Overall, the literature suggests that the therapy is associated with improved QOL as well as reduced opioid consumption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13285","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T22:41:02Z","timestamp":1582411262000},"page":"403-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Pain relief and improvement in quality of life with 10 kHz SCS therapy: Summary of clinical evidence"],"prefix":"10.1111","volume":"26","author":[{"given":"Dawood","family":"Sayed","sequence":"first","affiliation":[{"name":"University of Kansas School of Medicine Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Kallewaard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Rijnstate Hospital Arnhem Velp The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-7068","authenticated-orcid":false,"given":"Anand","family":"Rotte","sequence":"additional","affiliation":[{"name":"Nevro Corp. 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