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The genetic etiology of ET has not been well defined although a significant proportion (\u226550%) are familial cases. Linkage analysis and genome\u2010wide association studies (GWASs) have identified several risk variants. In recent years, whole\u2010exome sequencing of ET has revealed several specific causal variants in <jats:italic>FUS<\/jats:italic> (p.Q290X), <jats:italic>HTRA2<\/jats:italic> (p.G399S), and <jats:italic>TENM4<\/jats:italic> (c.4324 G&gt;A, c.4100C&gt;A, and c.3412G&gt;A) genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the genetic contribution of these three genes to ET, the protein\u2010coding sequences of <jats:italic>FUS, HTRA2<\/jats:italic>, and <jats:italic>TENM4<\/jats:italic> were analyzed in a total of 238 ET patients and 272 controls from eastern China using direct Sanger sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified two synonymous coding single nucleotide polymorphisms (SNPs), rs741810 and rs1052352 in <jats:italic>FUS<\/jats:italic>, and three previously reported synonymous SNPs, rs11237621, rs689369, and rs2277277 in <jats:italic>TENM4<\/jats:italic>. No nonsynonymous exonic variants were identified in these subjects. We found that the frequency of the rs1052352C allele was significantly higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) in the ET group than in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, our findings suggest that rs1052352 of <jats:italic>FUS<\/jats:italic> might contribute to ET risk in Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13305","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:31:57Z","timestamp":1584729117000},"page":"837-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genetic testing of <i>FUS<\/i>, <i>HTRA2,<\/i> and <i>TENM4<\/i> genes in Chinese patients with essential tremor"],"prefix":"10.1111","volume":"26","author":[{"given":"Ya\u2010Ping","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital Zhejiang 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