{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:48:11Z","timestamp":1783453691953,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["178544"],"award-info":[{"award-number":["178544"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Immunization with neural\u2010derived peptides (INDP) has demonstrated to be a promising therapy to achieve a regenerative effect in the chronic phase of the spinal cord injury (SCI). Nevertheless, INDP\u2010induced neurogenic effects in the chronic stage of SCI have not been explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>In this study, we analyzed the effect of INDP on both motor and sensitive function recovery; afterward, we assessed neurogenesis and determined the production of cytokines (IL\u20104, IL\u201010, and TNF alpha) and neurotrophic factors (BDNF and GAP\u201043). During the chronic stage of SCI, rats subjected to INDP showed a significant increase in both motor and sensitive recovery when compared to the control group. Moreover, we found a significant increase in neurogenesis, mainly at the central canal and at both the dorsal and ventral horns of INDP\u2010treated animals. Finally, INDP induced significant production of antiinflammatory and regeneration\u2010associated proteins in the chronic stages of SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that INDP has a neurogenic effect that could improve motor and sensitive recovery in the chronic stage of SCI. Moreover, our results also envision the use of INDP as a possible therapeutic strategy for other trauma\u2010related disorders like traumatic brain injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.13368","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T15:26:42Z","timestamp":1588260402000},"page":"650-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Immunization with neural\u2010derived peptides increases neurogenesis in rats with chronic spinal cord injury"],"prefix":"10.1111","volume":"26","author":[{"given":"Roxana","family":"Rodr\u00edguez\u2010Barrera","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Flores\u2010Romero","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Fern\u00e1ndez\u2010Presas","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda Facultad de Medicina Col. Universidad Nacional Aut\u00f3noma de M\u00e9xico Coyoacan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Incontri\u2010Abraham","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisset","family":"Navarro\u2010Torres","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Garc\u00eda\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Ju\u00e1rez\u2010Vignon Whaley","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Madrazo","sequence":"additional","affiliation":[{"name":"Proyecto CAMINA A.C Tlalpan Mexico"},{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Neurol\u00f3gicas CMN Siglo XXI IMSS Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-4689","authenticated-orcid":false,"given":"Antonio","family":"Ibarra","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) FCS Universidad An\u00e1huac M\u00e9xico Campus Norte Huixquilucan Mexico"},{"name":"Proyecto CAMINA A.C Tlalpan Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.164"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.13004\/kjnt.2015.11.2.180"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6250"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.17"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2003.07.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771504323004575"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00004.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.198972"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527317666181105101756"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-016-0331-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-016-0267-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.238615"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121854"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.04.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.03.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13092"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7065"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0109-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12763"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.12.006"},{"issue":"1","key":"e_1_2_7_22_1","first-page":"23","article-title":"Immunological control of adult neural stem cells","volume":"5","author":"Gonzalez\u2010Perez O","year":"2010","journal-title":"J Stem Cells"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12539"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4338"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085916"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0205-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2741\/3734"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.238615"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22771"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03402.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82458"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300320"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00693-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.266052"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01763.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22835"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu346"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230929"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E19"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0249"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040329"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.6.550"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.766"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00443"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032027"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.075"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00057"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.03.005"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00361"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13658"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00939"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.07.013"},{"issue":"1","key":"e_1_2_7_54_1","first-page":"63","article-title":"The expression of bFGF, GAP\u201043 and neurogenesis after cerebral ischemia\/reperfusion in rats","volume":"29","author":"Shi WQ","year":"2013","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2009.06.013"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0931"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcns.13368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T05:01:41Z","timestamp":1693976501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/cns.13368"],"URL":"https:\/\/doi.org\/10.1111\/cns.13368","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.14485\/v1","asserted-by":"object"}]},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"2019-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}