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The surface under the cumulative ranking curves (SUCRA) was used for ranking the efficacy of interventions. Sensitivity analysis and direct pairwise analysis were conducted to validate the main results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 68 RCTs consisting of 5890 patients were included. Disulfiram could significantly increase the AUD remission rates (OR 5.02, 1.97\u201012.95) and the percent abstinent days (MD 17.08, 3.48\u201030.93). Disulfiram was associated with the best efficacy in achieving remission (SUCRA 95.1%) and increasing abstinent days (SUCRA 87.6%). Noradrenaline reuptake inhibitor was significantly more efficacious than controls (SMD \u22122.44, \u22123.53 to \u22121.36) and have the first rank (SUCRA 99.0%) in reducing the scores of depression scales. Antiepileptics have relatively higher ranks in efficacy for both AUD and depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Disulfiram was associated with the best efficacy in achieving abstinence for comorbidity patients. Noradrenaline reuptake inhibitor was demonstrated to be associated with the best efficacy in reducing scores of depression scales. Antiepileptics might be beneficial to both alcohol\u2010related and depressive symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13437","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T05:35:29Z","timestamp":1595223329000},"page":"1185-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of pharmacotherapeutics for patients comorbid with alcohol use disorders and depressive symptoms\u2014A bayesian network meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-2456","authenticated-orcid":false,"given":"Jiande","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangpen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00122-1"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization.Global status report on alcohol and health.2018."},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization.Depression and other common mental disorders. 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