{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:26:55Z","timestamp":1793039215878,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>RAR\u2010related orphan receptor (<jats:italic>RORA<\/jats:italic>) involves in regulation of several biological processes including inflammation and circadian rhythm that probably are involved in migraine pathophysiology. In the current study, the association between <jats:italic>RORA<\/jats:italic> rs11639084 and rs4774388 variants and susceptibility to migraine were investigated in a sample of Iranian migraine patients for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a case\u2010control study including 400 participants, 200 migraineurs and 200 healthy controls, genotyping of <jats:italic>RORA<\/jats:italic> rs4774388 and rs11639084 polymorphisms was performed using tetra\u2010primer amplification refractory mutation system\u2013polymerase chain reaction (TP\u2010ARMS\u2010PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of rs4774388 C\/T and T\/T genotypes differed significantly between the studied groups. Moreover, an association was observed between rs4774388 and migraine under the recessive mode of inheritance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002; OR\u00a0=\u00a01.89.; CI\u00a0=\u00a01.25\u20102.87). The distribution of rs11639084 alleles and genotypes was not significantly different between migraineurs and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current results suggest <jats:italic>RORA<\/jats:italic>, as a molecular link, may explain inflammation and circadian rhythm dysfunction in migraine. Further studies in different ethnicities are required to confirm the function of <jats:italic>RORA<\/jats:italic> in migraine development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13453","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T06:15:57Z","timestamp":1599372957000},"page":"1315-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["RAR\u2010related orphan receptor A: One gene with multiple functions related to migraine"],"prefix":"10.1111","volume":"26","author":[{"given":"Sedigheh","family":"Farahani","sequence":"first","affiliation":[{"name":"Department of Genetics School of Biological Sciences Varamin\u2010Pishva Branch Islamic Azad University  Varamin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Solgi","sequence":"additional","affiliation":[{"name":"Department of Genetics School of Biological Sciences Varamin\u2010Pishva 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