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Molecular and morphological approaches were employed to test the time\u2010dependent alternation of \u03b1\u2010synuclein aggregation and the ultrastructure changes in the heart and nodose (NG)\/nucleus tractus solitarius (NTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood pressure (BP) and baroreflex sensitivity of DOPAL\u2010treated rats were significantly reduced accompanied with a time\u2010dependent change in orthostatic BP, consistent with altered echocardiography and cardiomyocyte mitochondrial ultrastructure. Notably, time\u2010dependent and collaborated changes in Mon\u2010\/Tri\u2010\u03b1\u2010synuclein were paralleled with morphological alternation in the NG and NTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These all demonstrate that early autonomic dysfunction mediated by vagal application of DOPAL highly suggests the plausible etiology of PD initiated from peripheral, rather than central site. It will provide a scientific basis for the prevention and early diagnosis of PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13589","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:44:13Z","timestamp":1611254653000},"page":"540-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Parkinson\u2010like early autonomic dysfunction induced by vagal application of DOPAL in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"Jie","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmacology (State\u2010Province Key Laboratories of Biomedicine\u2010Pharmaceutics of China Key Laboratory of Cardiovascular Medicine Research, Ministry of Education) College of Pharmacy Harbin Medical University Harbin China"},{"name":"School of Pharmaceutical Science Sun Yat\u2010Sen University Shenzhen 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