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However, stem cell\u2010derived mitochondria transplantation has been demonstrated to play an key part in metabolic rescue, which offers great promise for mitochondrial encephalomyopathies. Here, we summarize the present status of stem cell therapy for mitochondrial encephalomyopathy and discuss mitochondrial transfer routes and the protection mechanisms of stem cells. We also identify and summarize future perspectives and challenges for the treatment of these intractable disorders based on the concept of mitochondrial transfer from stem cells.<\/jats:p>","DOI":"10.1111\/cns.13618","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T16:33:48Z","timestamp":1612629228000},"page":"733-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Stem cell\u2010derived mitochondria transplantation: A promising therapy for mitochondrial encephalomyopathy"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-6631","authenticated-orcid":false,"given":"Kaiming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 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