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RNA\u2010seq was used to compare the spinal cord transcriptomes of wild\u2010type, untreated, and DF402\u2010treated FUS transgenic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DF402 delays the onset and slows the progression of pathology. We developed a CatWalk analysis protocol that allows detection of gait changes in FUS transgenic mice and the effect of DF402 on their gait already at early pre\u2010symptomatic stage. At this stage, a limited number of genes significantly change expression in transgenic mice and for 60% of these genes, DF402 treatment causes the reversion of the expression pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DF402 slows down the disease progression in the mouse model of ALS, which is consistent with previously reported neuroprotective properties of Dimebon and its other bioisosteres. These results suggest that these structures can be considered as lead compounds for further optimization to obtain novel medicines that might be used as components of complex ALS therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13637","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T07:53:23Z","timestamp":1616486003000},"page":"765-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A bioisostere of Dimebon\/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice"],"prefix":"10.1111","volume":"27","author":[{"given":"Kirill","family":"Chaprov","sequence":"first","affiliation":[{"name":"Institute of Physiologically Active Compounds Russian Academy of Science Chernogolovka Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rezvykh","sequence":"additional","affiliation":[{"name":"Engelhardt Institute of Molecular Biology Russian Academy of Sciences Moscow Russia"},{"name":"Moscow Institute of Physics and Technology Dolgoprudny Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei","family":"Funikov","sequence":"additional","affiliation":[{"name":"Engelhardt Institute of Molecular Biology Russian Academy of Sciences Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara A.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds Russian Academy of Science Chernogolovka Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina A.","family":"Lysikova","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds Russian Academy of Science Chernogolovka Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei V.","family":"Deykin","sequence":"additional","affiliation":[{"name":"Center for Precision Genome Editing and Genetic Technologies for Biomedicine Institute of Gene Biology Russian Academy of Sciences Moscow Russia"},{"name":"Laboratory of Genome Editing for Veterinary and Biomedicine Belgorod State National Research University Belgorod region Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail S.","family":"Kukharsky","sequence":"additional","affiliation":[{"name":"Institute of Physiologically Active Compounds Russian Academy of Science Chernogolovka Russia"},{"name":"Pirogov Russian National Research Medical University Moscow Russia"},{"name":"School of Biosciences Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Yu. 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