{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:05:38Z","timestamp":1770840338934,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize the clinical and histopathological characteristics and treatment outcomes of juvenile idiopathic inflammatory myopathies (JIIMs) with anti\u20103\u2010hydroxy\u20103\u2010methylglutaryl\u2010coenzyme A reductase (HMGCR) antibodies in a Chinese cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We detected anti\u2010HMGCR antibodies in a series of Chinese JIIM by ELISA and indirect immunofluorescence assay on HEK293 cells, and summarized the clinical findings of these anti\u2010HMGCR antibody\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 32 JIIM patients, 5 (15.63%) were found to be anti\u2010HMGCR antibody\u2010positive. The disease duration was 1.20\u00a0\u00b1\u00a00.45\u00a0months. Statin exposure was not found. Four patients had skin lesions, while typical pathological features of dermatomyositis such as perifascicular atrophy or myxovirus resistance protein A expression were not found. The mean creatine kinase level was 16771.60 U\/L. Among the four patients who received long\u2010term (10.46\u00a0\u00b1\u00a01.42\u00a0years) follow\u2010up, three exhibited favorable outcomes with prednisone and additional immunosuppressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study indicates that anti\u2010HMGCR antibodies may not be rare in Chinese JIIM. These anti\u2010HMGCR\u2010positive JIIMs were characterized by acute onset, substantially elevated creatine kinase level, and skin lesions without perifascicular changes in muscle pathology. The treatment outcome is generally favorable with the combination of steroid and immunosuppressant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.13658","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T10:23:37Z","timestamp":1619864617000},"page":"1041-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Juvenile idiopathic inflammatory myopathies with anti\u20103\u2010hydroxy\u20103\u2010methylglutaryl\u2010coenzyme A reductase antibodies in a Chinese cohort"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-4928","authenticated-orcid":false,"given":"Ying","family":"Hou","sequence":"first","affiliation":[{"name":"Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan 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