{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:31:04Z","timestamp":1774492264220,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060874"],"award-info":[{"award-number":["82060874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971828"],"award-info":[{"award-number":["81971828"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8206150249"],"award-info":[{"award-number":["8206150249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Glial scar formation impedes nerve regeneration\/reinnervation after spinal cord injury (SCI); therefore, removal of scar tissue is essential for SCI treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate whether removing a spinal cord and transplanting a vascularized pedicle of hemisected spinal cord from the spinal cord caudal to the transection can restore motor function, to aid in the treatment of future clinical spinal cord injuries. We developed a canine model. After removal of a 1\u2010cm segment of the thoracic (T10\u2013T11) spinal cord in eight beagles, a vascularized pedicle of hemisected spinal cord from the first 1.5\u00a0cm of the spinal cord caudal to the transection (cut along the posterior median sulcus of the spinal cord) was transplanted to bridge the transected spinal cord in the presence of a fusogen (polyethylene glycol, PEG) in four of the eight dogs. We used various forms of imaging, electron microscopy, and histologic data to determine that after our transplantation of a vascular pedicled hemisection to bridge the transected spinal cord, electrical continuity across the spinal bridge was restored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Motor function was restored following our transplantation, as confirmed by the re\u2010establishment of anatomic continuity along with interfacial axonal sprouting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, our findings suggest that SCI patients\u2014who have previously been thought to have irreversible damage and\/or paralysis\u2014may be treated effectively with similar operative techniques to re\u2010establish electrical and functional continuity following SCI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13696","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:57:14Z","timestamp":1624928234000},"page":"1182-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transplantation of a vascularized pedicle of hemisected spinal cord to establish spinal cord continuity after removal of a segment of the thoracic spinal cord: A proof\u2010of\u2010principle study in dogs"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-3913","authenticated-orcid":false,"given":"Shuai","family":"Ren","sequence":"first","affiliation":[{"name":"Hand and Microsurgery Center The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"State\u2010Province Key Laboratories of Biomedicine\u2010Pharmaceutics Harbin Medical University Harbin China"},{"name":"Global Initiative to Cure Paralysis (GICUP) 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