{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:59:36Z","timestamp":1790787576253,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Anti\u2010leucine\u2010rich glioma\u2010inactivated 1 (LGI1) autoimmune encephalitis (AE) is characterized by complex manifestations of seizures. Here, we report a new seizure semiology, attempt to classify the disease by semiology type, and explore the metabolic pattern of each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anti\u2010LGI1 AE patients were retrospectively screened between May 2014 and September 2019 in our tertiary epilepsy center. All enrolled patients had seizures during long\u2010range video electroencephalogram (EEG) recordings, and all patients (except one) underwent [<jats:sup>18<\/jats:sup>F] fluoro\u20102\u2010deoxyglucose (FDG) positron emission tomography (PET) scans. Voxel\u2010based metabolic analysis and z\u2010distribution analysis were carried out to determine the metabolic pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were enrolled. According to the patients\u2019 seizure semiology, we divided the patients into four groups: focal impaired awareness seizures (FIAS, <jats:italic>n<\/jats:italic>\u00a0=\u00a017), faciobrachial dystonic seizures (FBDS)\u2010only (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), FBDS\u2010plus (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), and focal aware motor seizures (FAMS) (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). No significant differences were found in the clinical manifestations or accessory tests except for the onset age (FIAS\u00a0&lt;\u00a0FBDS\u2010plus) and seizure semiology. This was the first study to extensively describe the clinical manifestations and EEG of FAMS in anti\u2010LGI1 AE patients. In addition, we found that the patients with different semiologies all showed a wide range of abnormal metabolism, which is not limited to the temporal regions and basal ganglia, and extends far beyond our previous interpretation of FDG\u2010PET data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed that FAMS can serve as a rare indicative seizure semiology of anti\u2010LGI1 AE and that individuals with this disease exhibited widespread functional network alterations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13707","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T07:42:11Z","timestamp":1626939731000},"page":"1173-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Recognition of seizure semiology and semiquantitative FDG\u2010PET analysis of anti\u2010LGI1 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