{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:59:09Z","timestamp":1792299549975,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This follow\u2010up study aimed to examine the 8\u2010year efficacy and safety of subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD) in southern China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The follow\u2010up data of 10 patients with PD undergoing STN\u2010DBS were analyzed. Motor symptoms were assessed before and 1, 3, 5, and 8\u00a0years after the surgery with stimulation\u2010on in both off\u2010medication (off\u2010med) and on\u2010medication (on\u2010med) status using the Unified Parkinson's disease Rating Scale Part III. The quality of life was assessed using the 39\u2010item Parkinson's Disease Questionnaire. The sleep, cognition, and emotion were evaluated using a series of nonmotor scales. Levodopa equivalent daily dose (LEDD) and stimulation parameters were recorded at each follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The motor symptoms were improved by 50.9%, 37.7%, 36.7%, and 37.3% in 1, 3, 5, and 8\u00a0years, respectively, in the off\u2010med \/ stimulation\u2010on status compared with the baseline. The quality of life improved by 39.7% and 56.1% in 1 and 3\u00a0years, respectively, but declined to the preoperative level thereafter. The sleep, cognition, and emotion were mostly unchanged. LEDD reduced from 708.1\u00a0\u00b1\u00a0172.5\u00a0mg to 330\u00a0\u00b1\u00a0207.8\u00a0mg in 8\u00a0years. The stimulation parameters, including amplitude, pulse width, and frequency, were 2.77\u00a0\u00b1\u00a00.49\u00a0V, 71.3\u00a0\u00b1\u00a012.8\u00a0\u03bcs, and 121.5\u00a0\u00b1\u00a021\u00a0Hz, respectively, in 8\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term therapeutic efficacy of STN\u2010DBS could be achieved even with relatively low stimulation intensity and medication dosage for PD patients in southern China. Motor improvement and medication reduction were maintained through the 8\u2010year follow\u2010up, but improvement in quality of life lasted for only 3\u00a0years. No definite changes was found in nonmotor symptoms after STN\u2010DBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13713","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:44:44Z","timestamp":1628149484000},"page":"1366-1373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Eight\u2010year follow\u2010up outcome of subthalamic deep brain stimulation for Parkinson\u2019s disease: Maintenance of therapeutic efficacy with a relatively low levodopa dosage and stimulation intensity"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-9957","authenticated-orcid":false,"given":"Lulu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology The First Affiliated 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