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However, the clinical features of mild cognitive impairment (MCI) in pPD remain unknown. Our study aimed to evaluate the frequency and clinical features of mild cognitive impairment of pPD in the elderly in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cross\u2010sectional community\u2010based study recruited 2688 participants aged \u226550\u00a0years. Subjects were diagnosed with pPD according to the MDS criteria. Overall, 39 pPD and 22\u00a0healthy controls underwent comprehensive clinical and neuropsychological assessment. MCI was also diagnosed by the MDS criteria. Next, we investigated the relationship between clinical factors and cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 2,663 dementia\u2010free and Parkinson disease (PD)\u2010free participants, 55\u00a0met the criteria for pPD (2.1%) and 23 pPD met the criteria for MCI. Memory, attention\/working memory, and executive function were the most frequent impaired domains, and amnestic MCI multidomain phenotype was the most frequent MCI subtype (69.57%) in pPD. Additionally, correlation analysis revealed that the global cognitive performance was negatively related to UPDRS\u2010III score (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.456, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MCI, specifically impairment in memory, attention\/working memory, and executive domain, is present at the prodromal stage of PD. In addition, cognitive performance is correlated with motor symptoms in pPD. Our results reflect that cognitive profile, combined with motor symptoms, can help clinicians to identify individuals with pPD early, as those would be the optimal candidates for neuroprotective therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13766","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T09:32:17Z","timestamp":1637919137000},"page":"259-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Characterizing mild cognitive impairment in prodromal Parkinson\u2019s disease: A community\u2010based study in China"],"prefix":"10.1111","volume":"28","author":[{"given":"Chenxi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Nanjing Medical University  Nanjing 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