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Considerable research efforts have been directed toward identifying new strategies to effectively treat SCI. Governor Vessel electro\u2010acupuncture (GV\u2010EA), used in traditional Chinese medicine, combines acupuncture with modern electrical stimulation. It has been shown to improve the microenvironment of injured spinal cord (SC) by increasing levels of endogenous neurotrophic factors and reducing inflammation, thereby protecting injured neurons and promoting myelination. In addition, axons extending from transplanted stem cell\u2010derived neurons can potentially bridge the two severed ends of tissues in a transected SC to rebuild neuronal circuits and restore motor and sensory functions. However, every single treatment approach to severe SCI has proven unsatisfactory. Combining different treatments\u2014for example, electro\u2010acupuncture (EA) with adult stem cell transplantation\u2014appears to be a more promising strategy. In this review, we have summarized the recent progress over the past two decades by our team especially in the use of GV\u2010EA for the repair of SCI. By this strategy, we have shown that EA can stimulate the nerve endings of the meningeal branch. This would elicit the dorsal root ganglion neurons to secrete excess amounts of calcitonin gene\u2010related peptide centrally in the SC. The neuropeptide then activates the local cells to secrete neurotrophin\u20103 (NT\u20103), which mediates the survival and differentiation of donor stem cells overexpressing the NT\u20103 receptor, at the injury\/graft site of the SC. Increased local production of NT\u20103 facilitates reconstruction of host neural tissue such as nerve fiber regeneration and myelination. All this events in sequence would ultimately strengthen the cortical motor\u2010evoked potentials and restore the motor function of paralyzed limbs. The information presented herein provides a basis for future studies on the clinical application of GV\u2010EA and adult stem cell transplantation for the treatment of SCI.<\/jats:p>","DOI":"10.1111\/cns.13813","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T09:58:56Z","timestamp":1645091936000},"page":"635-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Electro\u2010acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of literature"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-5792","authenticated-orcid":false,"given":"Yuan\u2010Shan","family":"Zeng","sequence":"first","affiliation":[{"name":"Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat\u2010sen University) Ministry of Education  Guangzhou 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