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However, the current therapeutic strategies for SAH are unsatisfactory. Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), as the third gas signaling molecule after carbon monoxide and nitric oxide, has been widely studied recently. There is growing evidence that H<jats:sub>2<\/jats:sub>S has a promising future in the treatment of central nervous system diseases. In this review, we focus on the effects of H<jats:sub>2<\/jats:sub>S in experimental SAH and elucidate the underlying mechanisms. We demonstrate that H<jats:sub>2<\/jats:sub>S has neuroprotective effects and significantly reduces secondary damage caused by SAH via antioxidant, antiinflammatory, and antiapoptosis mechanisms, and by alleviating cerebral edema and vasospasm. 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