{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:44:00Z","timestamp":1787629440002,"version":"build-2736575974"},"reference-count":80,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830033"],"award-info":[{"award-number":["81830033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61761166004"],"award-info":[{"award-number":["61761166004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>The efficacy and safety of posterior subthalamic area (PSA) and ventral intermediate nucleus (VIM) deep brain stimulation (DBS) in the treatment of essential tremor (ET) have not been compared in large\u2010scale studies. We conducted a secondary analysis to identify the superior target of ET\u2010DBS treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, Cochrane Library, and Google Scholar were searched for relevant studies before September 2021. The tremor\u2010suppression efficacy and rate of stimulation\u2010related complications (SRCR) after PSA\u2010DBS and VIM\u2010DBS treating ET were quantitatively compared. Secondary outcomes, including tremor subitem scores and quality of life results, were also analyzed. Subgroup analyses were further conducted to stratify by follow\u2010up (FU) periods and stimulation lateralities. This study was registered in Open Science Framework (DOI:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.17605\/OSF.IO\/7VJQ8\">10.17605\/OSF.IO\/7VJQ8<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 23 studies including 122 PSA\u2010DBS patients and 326 VIM\u2010DBS patients were analyzed. The average follow\u2010up time was 12.81 and 14.66\u2009months, respectively. For the percentage improvement of total tremor rating scale (TRS) scores, PSA\u2010DBS was significantly higher, when compared to VIM\u2010DBS in the sensitivity analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030) and main analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043). The SRCR after VIM\u2010DBS was higher than that of PSA\u2010DBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022), and bilateral PSA\u2010DBS was significantly superior to both bilateral and unilateral VIM\u2010DBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provided level IIIa evidence that PSA\u2010DBS was more effective and safer for ET than VIM\u2010DBS in 12\u201324\u2009months, although both PSA\u2010DBS and VIM\u2010DBS were effective in suppressing tremor in ET patients. Further prospective large\u2010scale randomized clinical trials are warranted in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.13878","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T12:44:23Z","timestamp":1654865063000},"page":"1380-1392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Which one is the superior target? A comparison and pooled analysis between posterior subthalamic area and ventral intermediate nucleus deep brain stimulation for essential tremor"],"prefix":"10.1111","volume":"28","author":[{"given":"Houyou","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Neurostimulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Neurostimulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-0574","authenticated-orcid":false,"given":"Jianguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Neurostimulation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.1397"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4485"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz085"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu250"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007134"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008875"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.01.025"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.12.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22758"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1737017"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20960"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318236a809"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005956"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.05.014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12565"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.11.064"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.Ed000142"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323216"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.12.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.222992"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448926"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_234_18"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.4.JNS18373"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00016"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.9.JNS191646"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.1.0048"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-822789"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.4.626"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690701552278"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000325492.58799.35"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02958.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.11.006"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145623"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12337"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1741-8"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.008"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200101)16:1<140::aid-mds1025>3.0.co;2-t"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.46.4.1150"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199909)14:5<847::aid-mds1021>3.0.co;2-g"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1089"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.2.218"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.3.0400"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21087"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-120"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.03.012"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.03.017"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.Jns162487"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afj072"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.09.024"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.01.006"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1053-8119(02)00043-5"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw074"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww145"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab074"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478270"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000000540"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz236"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000134764.76223.4b"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opab324"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12588"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.09.004"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13770"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws026"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1597894"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2019.105466"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq267"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1044\/2014_jslhr-s-13-0155"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt304"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061855"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww223"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342497"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.04.015"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1109\/embc44109.2020.9175433"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.09.002"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27096"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512231"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323656"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13802"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T06:32:27Z","timestamp":1692858747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,10]]},"references-count":80,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/cns.13878"],"URL":"https:\/\/doi.org\/10.1111\/cns.13878","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,10]]},"assertion":[{"value":"2022-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}