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This approach can lead to high burdens on the heart and decreased hematocrit in the scenario of loading a high amount of liquid for longtime usage. Therefore, autologous blood is utilized as perfusate to circumvent those side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, a prototype instrument with an autologous blood cooling system was developed and further evaluated by a mathematical model for brain temperature estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypothermia could be achieved due to the adequate cooling capacity of the prototype system, which could provide the lowest cooling temperature into the blood vessel of 10.5\u00b0C at 25\u2009rpm (209.7\u2009\u00b1\u20090.8\u00a0ml\/min). And, the core body temperature did not alter significantly (\u22120.7\u2009~\u2009\u22120.2\u00b0C) after 1\u2010h perfusion. The cooling rate and temperature distributions of the brain were analyzed, which showed a 2\u00b0C decrease within the initial 5\u00a0min infusion by 44\u2009ml\/min and 13.7\u00b0C perfusate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This prototype instrument system could safely cool simulated blood in vitro and reperfuse it to the target cerebral blood vessel. This technique could promote the clinical application of an autologous blood perfusion system for stroke therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.13883","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T03:39:04Z","timestamp":1655264344000},"page":"1303-1314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The intra\u2010arterial selective cooling infusion system: A\u00a0mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"Miaowen","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Instrumentation and Optoelectronic Engineering Beihang University  Beijing China"},{"name":"Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University  Beijing 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