{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:54:35Z","timestamp":1789757675874,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to find where and how noise\u2010induced cochlear hearing loss affects the central nervous system during the early state and identify the neural substrate for aberrant patterns that mediating noise\u2010related anxiety\u2212\/depression\u2010 like behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Broad band noise with 122\u2009dB for 2\u00a0hours was conducted to induce hearing loss. We defined 0\u00a0day (N0D) and 10\u2009days (N10D) post noise as the acute and sub\u2010acute period. Behavioral tests (Open field test and light\/dark test) and resting\u2010state fMRI were computed to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis using the anterior cingulate cortex as a seed was computed to reveal the spatial distribution beyond auditory network during both periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anxiety\u2212\/depression\u2010like behaviors were found in rats with noise exposure. Between\u2010group analysis revealed that N0D rats displayed widespread reductions in functional connectivity, spanning primary somatosensory cortex, medial geniculate body, inferior colliculus, cingulate cortex, cerebellar lobule comparing with N10D rats and a similar pattern was also occurred in comparison with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, an \u201cacoustic\u2010causing\u201d network accounting for distress and gating of noise exposure related anxiety\/depression was proposed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13896","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T10:41:03Z","timestamp":1655808063000},"page":"1547-1556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Altered resting\u2010state functional connectivity of the anterior cingulate cortex in rats post noise 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